Co-immunization with interlukin-18 enhances the protective efficacy of liposomes encapsulated recombinant Cu-Zn superoxide dismutase protein against Brucella abortus

Singha Harisankar; Mallick Amirul Islam; Jana Chandrakanta; Fatima Nishat; Owais Mohammad; Chaudhuri Pallab .

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Co-immunization with interlukin-18 enhances the protective efficacy of liposomes encapsulated recombinant Cu-Zn superoxide dismutase protein against Brucella abortus

机译：与白介素18共同免疫可增强脂质体包裹的重组铜锌超氧化物歧化酶蛋白对布鲁氏菌流产的保护作用

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Brucellosis is a worldwide zoonotic disease caused by Brucella abortus and a number of closely related species. Brucellosis has severe impact on the health and economic prosperity of the developing countries due to the persistent nature of infection and unavailability of effective control measures. The Cu-Zn superoxide dismuatse (SOD) protein of Brucella have been extensively studied as a major antigen involved in bacterial evading mechanism of host defence. Being a critical pro-inflammatory cytokine interleukin-18 (IL-18) plays key role in induction of immune mediated protection against intracellular pathogens. In the present study, we aimed to investigate the immunogenic potential of fusogenic liposomes (escheriosomes) encapsulated recombinant Cu-Zn SOD (rSOD) protein alone or in combination with recombinant IL-18 (rIL-18). Escheriosomes encapsulated rSOD mediated immune responses were further increased upon co-immunization with rIL-18. Furthermore, immunization with escheriosomes encapsulated rSOD alone or in combination with rIL-18, increased resistance in mice against challenge with B. abortus 544

机译：布鲁氏菌病是一种全球性的人畜共患疾病，由流产布鲁氏菌和许多密切相关的物种引起。由于感染的持续性和缺乏有效的控制措施，布鲁氏菌病对发展中国家的健康和经济繁荣具有严重影响。布鲁氏菌的铜锌超氧化物歧化酶（SOD）蛋白已被广泛研究为参与宿主防御细菌逃逸机制的主要抗原。作为关键的促炎细胞因子白介素18（IL-18）在诱导免疫介导的针对细胞内病原体的保护中起关键作用。在本研究中，我们旨在研究融合或单独重组IL- 18（rIL-18）融合的脂质体（escheriosomes）封装的重组Cu-Zn SOD（rSOD）蛋白的免疫原性潜力。与rIL-18共免疫后，封装了rSOD介导的免疫反应的大肠埃希氏体进一步增加。此外，用单独包裹rSOD或与rIL-18结合的包裹sEsiosome的免疫接种可增强小鼠对流产双歧杆菌攻击的抵抗力544

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《Vaccine》 |2011年第30期|共8页
作者
Singha Harisankar; Mallick Amirul Islam; Jana Chandrakanta; Fatima Nishat; Owais Mohammad; Chaudhuri Pallab .;
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copper-zinc-superoxide dismutase: copper-zinc SOD; 9054-89-1; EC 1.15.1.1; recombinant; recombinant interleukin-18: immunologic-drug; fusogenic liposome encapsulated recombinant copper-zinc superoxide dismutase: immunologic-drug; phar; Brucella RB-51 vaccine: immunologic-drug; immunostimulant-drug; vaccine; drug resistance; immune response; cellular response; humoral response; immunogenic potential;

机译：铜锌超氧化物歧化酶：铜锌超氧化物歧化酶;9054-89-1;EC 1.15.1.1;重组;重组白介素18：免疫药;融合融合脂质体的重组铜锌超氧化物歧化酶：免疫药;药相;布鲁氏菌RB-51疫苗：免疫药物;免疫刺激药物;疫苗;耐药性;免疫反应;细胞反应;体液反应;免疫原性;

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专利

1. Co-immunization with interlukin-18 enhances the protective efficacy of liposomes encapsulated recombinant Cu-Zn superoxide dismutase protein against Brucella abortus [J] . Singha Harisankar, Mallick Amirul Islam, Jana Chandrakanta, Vaccine . 2011,第29a30期

机译：与白介素18共同免疫可增强脂质体包裹的重组铜锌超氧化物歧化酶蛋白对布鲁氏菌流产的保护作用
2. Cattle serologically positive for Brucella abortus have antibodies to B. abortus Cu-Zn superoxide dismutase. [J] . L B Tabatabai, S G Hennager Clinical and diagnostic laboratory immunology . 1994,第5期

机译：血清学上对布鲁氏菌流产呈阳性的牛具有针对流产布鲁氏菌的铜锌超氧化物歧化酶的抗体。
3. Induction of Immune Responses by Two Recombinant Proteins of Brucella abortus, Outer Membrane Proteins 2b Porin and Cu/Zn Superoxide Dismutase, in Mouse Model [J] . Kyung Yong Sung, Myunghwan Jung, Min-Kyoung Shin, Journal of microbiology and biotechnology . 2014,第6期

机译：在小鼠模型中由流产布鲁氏菌的两种重组蛋白，外膜蛋白2b孔蛋白和铜/锌超氧化物歧化酶诱导的免疫应答
4. Generation of baculovirus-Brucella abortus heat shock protein recombinants; mice immune responses against the recombinants, and B. abortus superoxide dismutase and L7/L12 recombinant proteins. [D] . Bae, Joo-eun. 1999

机译：杆状病毒-流产布鲁氏菌热激蛋白重组体的产生；小鼠对重组体以及流产双歧杆菌超氧化物歧化酶和L7 / L12重组蛋白的免疫应答。
5. An RNA Vaccine Based on Recombinant Semliki Forest Virus Particles Expressing the CuZn Superoxide Dismutase Protein of Brucella abortus Induces Protective Immunity in BALB/c Mice [O] . Angel A. Oñate, Gabriel Donoso, Gustavo Moraga-Cid, 2005

机译：表达重组布鲁氏菌流产铜锌超氧化物歧化酶蛋白的Semliki森林病毒颗粒的RNA疫苗诱导BALB / c小鼠的保护性免疫。
6. An RNA Vaccine Based on Recombinant Semliki Forest Virus Particles Expressing the Cu,Zn Superoxide Dismutase Protein of Brucella abortus Induces Protective Immunity in BALB/c Mice [O] . Oñate, Angel A., Donoso, Gabriel, Moraga-Cid, Gustavo, 2005

机译：表达重组布鲁氏菌流产铜，锌超氧化物歧化酶蛋白的Semliki森林病毒颗粒的RNA疫苗诱导BALB / c小鼠的保护性免疫。

Co-immunization with interlukin-18 enhances the protective efficacy of liposomes encapsulated recombinant Cu-Zn superoxide dismutase protein against Brucella abortus

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