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首页> 外文期刊>Vaccine >Measles outbreak in Burkina Faso, 2009: a case-control study to determine risk factors and estimate vaccine effectiveness.
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Measles outbreak in Burkina Faso, 2009: a case-control study to determine risk factors and estimate vaccine effectiveness.

机译：布基纳法索2009年麻疹暴发：一项病例对照研究，以确定危险因素和评估疫苗有效性。

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Objective: We investigated a large measles outbreak that occurred in 2009 in Burkina Faso in order to describe the epidemic, assess risk factors associated with measles, and estimate measles vaccine effectiveness. Methods: We reviewed national surveillance and measles vaccine coverage data, and conducted a case-control study in three geographic areas. Case-patients were randomly selected from the national case-based measles surveillance database or, when a case-patient could not be traced, were persons in the same community who experienced an illness meeting the WHO measles clinical case definition. Controls were matched to the same age stratum (age 1-14 years or age 15-30 years) and community as case-patients. Risk factors were assessed using conditional logistic regression. Results: Lack of measles vaccination was the main risk factor for measles in all three geographic areas for children aged 1-14 years (adjusted matched odds ratio [aMOR] [95% confidence interval (CI)], 19.4 [2.4-155.9], 5.9 [1.6-21.5], and 6.4 [1.8-23.0] in Bogodogo, Zorgho, and Sahel, respectively) and persons aged 15-30 years (aMOR [95% CI], 3.2 [1.1-9.7], 19.7 [3.3-infinity], 8.0 [1.8-34.8] in Bogodogo, Zorgho, and Sahel, respectively). Among children aged 1-14 years, VE of any measles vaccination prior to 2009 was 94% (95% CI, 45-99%) in Bogodogo, 87% (95% CI, 37-97%) in Zorgho, and 84% (95% CI, 41-96%) in Sahel. Main reasons for not receiving measles vaccination were lack of knowledge about vaccination campaigns or need for measles vaccination and absence during vaccination outreach or campaign activities. Conclusion: These results emphasize the need for improved strategies to reduce missed opportunities for vaccination and achieve high vaccination coverage nationwide in order to prevent large measles outbreaks and to continue progress toward measles mortality reduction.
机译：目的：我们调查了2009年在布基纳法索发生的一次大规模麻疹暴发，以描述这种流行病，评估与麻疹有关的危险因素并评估麻疹疫苗的有效性。方法：我们回顾了国家监测和麻疹疫苗覆盖率数据，并在三个地理区域进行了病例对照研究。从国家基于病例的麻疹监测数据库中随机选择病例患者，或者在无法追踪病例患者的情况下，是同一社区中经历过符合WHO麻疹临床病例定义的疾病的患者。对照组与病例患者在相同的年龄层（1-14岁或15-30岁）和社区相匹配。使用条件逻辑回归评估风险因素。结果：麻疹疫苗缺乏是这三个地理区域内1-14岁儿童麻疹的主要危险因素（调整后的匹配优势比[aMOR] [95％置信区间（CI）]，19.4 [2.4-155.9]， Bogodogo，Zorgho和Sahel分别为5.9 [1.6-21.5]和6.4 [1.8-23.0]）和15-30岁的年龄段的人（aMOR [95％CI]，3.2 [1.1-9.7]，19.7 [3.3-无穷大]，分别在Bogodogo，Zorgho和Sahel中为8.0 [1.8-34.8]。在1-14岁的儿童中，Bogodogo之前的2009年之前任何麻疹疫苗接种的VE分别为94％（95％CI，45-99％），Zorgho和87％（95％CI，37-97％），以及84％ （95％CI，41-96％）在萨赫勒地区。不接受麻疹疫苗接种的主要原因是缺乏有关疫苗接种运动的知识或需要进行麻疹疫苗接种以及在疫苗接种外展或活动期间缺乏麻疹疫苗。结论：这些结果强调需要改进策略以减少错过的疫苗接种机会并在全国范围内实现较高的疫苗接种覆盖率，以防止大规模的麻疹暴发并继续朝着降低麻疹死亡率的方向发展。

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