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首页> 外文期刊>Vaccine >Improvac does not modify the expression and activities of the major drug metabolizing enzymes cytochrome P450 3A and 2C in pigs
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Improvac does not modify the expression and activities of the major drug metabolizing enzymes cytochrome P450 3A and 2C in pigs

机译：Improvac不会改变猪主要药物代谢酶细胞色素P450 3A和2C的表达和活性

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In the present study, we investigated hepatic mRNA expression and activities of CYP3A and 2C in entire, surgically castrated and pigs vaccinated with Improvac. Additionally, we examined the mRNA expression of the two nuclear receptors pregnane X receptor (PXR) and constitutive androstane receptor (CAR), known to regulate CYP3A and 2C mRNA expression, respectively. Activities of CYP3A and 2C were estimated as a rate of 7-benzyloxy-4-trifluoromethylcoumarin and 7-benzyloxyquinoline metabolism (CYP3A) and tolbutamide metabolism (CYP2C). We found no effect of Improvac treatment or surgical castration on either CYP3A or 2C activities. Similarly, the mRNA expressions of CYP3A29, 2C33 and PXR were not changed. CAR mRNA expression differed only between entire and surgically castrated male pigs (p = 0.005), being greater in surgically castrated pigs. Our results indicated that neither CYP3A nor 2C are affected by Improvac. (C) 2012 Elsevier Ltd. All rights reserved.
机译：在本研究中，我们调查了Improvac免疫接种的整只，cast割的猪和肝脏中CYP3A和2C的肝mRNA表达及活性。此外，我们检查了已知分别调节CYP3A和2C mRNA表达的两个核受体孕烷X受体（PXR）和组成型雄烷烃受体（CAR）的mRNA表达。 CYP3A和2C的活性以7-苄氧基-4-三氟甲基香豆素和7-苄氧基喹啉代谢（CYP3A）和甲苯丁酰胺代谢（CYP2C）的速率估算。我们发现Improvac治疗或手术去势对CYP3A或2C活性均无影响。同样，CYP3A29、2C33和PXR的mRNA表达未改变。 CAR mRNA表达仅在整只和and割的公猪之间有所不同（p = 0.005），在surgical割的猪中更高。我们的结果表明，Improvac既不影响CYP3A也不影响2C。 （C）2012 Elsevier Ltd.保留所有权利。

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