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首页> 外文期刊>Vaccine >Control of pandemic (H1N1) 2009 influenza virus infection of ferret lungs by non-adjuvant-containing pandemic and seasonal vaccines
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Control of pandemic (H1N1) 2009 influenza virus infection of ferret lungs by non-adjuvant-containing pandemic and seasonal vaccines

机译：通过不含佐剂的大流行和季节性疫苗控制雪貂肺部2009年大流行（H1N1）流感病毒感染

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The pandemic H1N1 2009 influenza virus caused relatively mild disease in most infected people but some suffered extensively from primary lung infection, many more than would have occurred with seasonal influenza infection. Early commercially available pandemic H1N1 vaccines did not contain adjuvant, as did many of the subsequent vaccines, and could not stop infection with the pandemic virus in vaccinated ferrets. Nevertheless, we showed that virus loads in the lungs were greatly diminished in ferrets vaccinated once with an unadjuvanted pandemic vaccine and challenged with 10(6) EID50 wildtype A/California/07/2009 (H1N1). In addition, a single inoculation with seasonal vaccine showed beneficial reduction in pandemic pulmonary virus loads in the absence of any detectable cross-reactive serological responses. Ferrets primed with either seasonal or pandemic vaccine and then boosted with pandemic vaccine also showed less extensive lung infection when challenged with a tenfold higher dose of pandemic virus. These results implicate non-classical protective mechanisms that prevent severe pulmonary disease but not viral shedding and imply that particular non-adjuvanted vaccines may have retained the ability to induce these responses. (C) 2012 Elsevier Ltd. All rights reserved.
机译：2009年H1N1大流行性流感病毒在大多数感染者中引起相对轻度的疾病，但有些人遭受原发性肺部感染的严重影响，比季节性流感感染所造成的感染要严重得多。早期的大流行H1N1大流行疫苗不像其他后续疫苗那样含有佐剂，也无法阻止接种的雪貂感染大流行性病毒。尽管如此，我们显示，用无佐剂的大流行疫苗接种雪貂并用10（6）EID50野生型A /加利福尼亚07/2009（H1N1）攻击的雪貂，肺中的病毒载量大大降低。另外，在没有任何可检测到的交叉反应血清反应的情况下，单次接种季节性疫苗显示出大流行性肺病毒载量的有益降低。用季节性或大流行性疫苗接种的雪貂，再用大流行性疫苗加强免疫，当受到高剂量大流行性病毒10倍攻击时，其肺部感染也较少。这些结果暗示了预防严重的肺部疾病但不能引起病毒脱落的非经典保护机制，并暗示特定的非佐剂疫苗可能保留了诱导这些反应的能力。 （C）2012 Elsevier Ltd.保留所有权利。

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