Model for competition from self during passive immunization, with application to broadly neutralizing antibodies for HIV.

Ali Tabei SM; Li Y; Weigert M; Dinner AR

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Model for competition from self during passive immunization, with application to broadly neutralizing antibodies for HIV.

机译：被动免疫过程中自我竞争的模型，适用于广泛中和HIV抗体。

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We propose a mathematical model to interpret observations concerning the behavior of broadly neutralizing antibodies for chronic HIV in vivo. The model enables us to identify a threshold antibody level that must be achieved to decrease the viral load effectively. Although this threshold has not been reached in existing passive immunization studies, it is within range of humoral immune responses, suggesting that therapeutic vaccines are feasible. In an appendix, we develop a model of passive immunization against influenza, and acute infection

机译：我们提出一个数学模型来解释有关体内慢性HIV广泛中和抗体行为的观察结果。该模型使我们能够确定必须有效降低病毒载量的抗体阈值水平。尽管在现有的被动免疫研究中尚未达到此阈值，但它在体液免疫应答的范围内，这表明治疗性疫苗是可行的。在附录中，我们开发了一种针对流感和急性感染的被动免疫模型

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《Vaccine》 |2012年第3期|共7页
作者
Ali Tabei SM; Li Y; Weigert M; Dinner AR;
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正文语种 eng
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关键词
HIV; Broadly neutralizing antibodies; Passive immunization; Mathematical model; Self epitopes;

机译：HIV;广泛中和抗体;被动免疫;数学模型;自身表位;

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专利

1. Model for competition from self during passive immunization, with application to broadly neutralizing antibodies for HIV. [J] . Ali Tabei SM, Li Y, Weigert M, Vaccine . 2012,第3期

机译：被动免疫过程中自我竞争的模型，适用于广泛中和HIV抗体。
2. Report of the Cent Gardes HIV Vaccine Conference the B-cell response to HIV. Part 1: Broadly neutralizing antibodies Fondation Merieux Conference Center, Veyrier du Lac, France, 5-7 November 2012. [J] . Girard M. P., Picot V., Longuet C., Vaccine . 2013,第29期

机译：Cent Gardes HIV疫苗会议的报告B细胞对HIV的反应。第1部分：广泛中和抗体2012年11月5日至7日，法国Veyrier du Lac基金会Merieux会议中心。
3. Structure and design of broadly-neutralizing antibodies against HIV. [J] . Seong Eon Ryu, Wayne A Hendrickson Molecules and cells . 2012,第3期

机译：抗HIV的广泛中和抗体的结构和设计。
4. CO-FORMULATION OF BROADLY NEUTRALIZING ANTIBODIES 3BNC117 AND PGT121: ANALYTICAL CHALLENGES DURING PRE-FORMULATION CHARACTERIZATION AND STORAGE STABILITY STUDIES [C] . Ashaben Patel, Vineet Gupta, John M. Hickey, Conference on vaccine technology VI . 2018

机译：共同中和抗体3BNC117和PGT121的共同配制：配制前表征和储存稳定性研究中的分析挑战
5. Broadly Neutralizing Antibodies and Broadly Neutralizing Sera: Insights into HIV-1 Vaccine Design [D] . Walker, Laura M. 2011

机译：广泛中和抗体和广泛中和血清：对HIV-1疫苗设计的见解
6. Protection of Humanized Mice From Repeated Intravaginal HIV Challenge by Passive Immunization: A Model for Studying the Efficacy of Neutralizing Antibodies In Vivo [O] . Maud Deruaz, Brian Moldt, Khoa M. Le, -1

机译：通过被动免疫保护人源化小鼠免受重复性阴道内HIV挑战：研究体内中和抗体功效的模型
7. Optimizing immunization protocols to elicit broadly neutralizing antibodies [O] . Kayla G. Sprenger, Joy E. Louveau, Arup K. Chakraborty 2020

机译：优化免疫协议，以引发广泛中和抗体

Model for competition from self during passive immunization, with application to broadly neutralizing antibodies for HIV.

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