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首页> 外文期刊>Vaccine >Protective role of antibodies induced by Brucella melitensis B115 against B. melitensis and Brucella abortus infections in mice.
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Protective role of antibodies induced by Brucella melitensis B115 against B. melitensis and Brucella abortus infections in mice.

机译：布鲁氏杆菌B115诱导的抗体对B的保护作用。小鼠中的肉毒杆菌感染和流产布鲁氏菌感染。

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摘要

It has been demonstrated that antibodies specific for O-PS antigen of Brucella smooth strains are involved in the protective immunity of brucellosis. Since the rough strain Brucella melitensis B115 was able to protect mice against wild Brucella strains brucellosis despite the lack of anti-OPS antibodies, in this study we evaluated the biological significance of antibodies induced by this strain, directed to antigens other than O-PS, passively tranferred to untreated mice prior to infection with Brucella abortus 2308 and B. melitensis 16 M virulent strains. The protective ability of specific antisera collected from mice vaccinated with B. melitensis B115, B. abortus RB51 and B. abortus S19 strains was compared. The results indicated that antibodies induced by B115 were able to confer a satisfactory protection, especially against B. abortus 2308, similar to that conferred by the antiserum S19, while the RB51 antiserum was ineffective. These findings suggest that antibodies induced by B115 could act as opsonins as well as antibodies anti-O-PS, thus triggering more efficient internalization and degradation of bacteria within phagocytes. This is the first study assessing the efficacy of antibodies directed to antigens other than O-PS in the course of brucellosis infection.Digital Object Identifier http://dx.doi.org/10.1016/j.vaccine.2012.04.009
机译：已经证明对布鲁氏菌光滑菌株的O-PS抗原具有特异性的抗体与布鲁氏菌病的保护性免疫有关。尽管缺乏抗OPS抗体，粗糙的菌株 Bulcuella melitensis B115仍能保护小鼠免受野生的 Brucella 布鲁氏菌病的影响，因此在这项研究中我们评估了抗体的生物学意义由该菌株诱导的，针对O-PS以外抗原的抗原，在感染流产布鲁氏菌2308和B之前被被动转移到未经处理的小鼠中。肉毒杆菌16 M强毒株。从用iB接种的小鼠中收集的特异性抗血清的保护能力。 melitensis B115， B。流产 RB51和 B。比较了流产S19菌株。结果表明，由B115诱导的抗体能够赋予令人满意的保护，尤其是针对B。流产2308，与抗血清S19产生的流产相似，而RB51抗血清无效。这些发现表明，由B115诱导的抗体既可以作为调理素，又可以作为抗O-PS的抗体，从而触发吞噬细胞内细菌更有效的内化和降解。这是第一项评估针对布氏杆菌病感染过程中针对O-PS以外抗原的抗体的功效的研究。数字对象标识符http://dx.doi.org/10.1016/j.vaccine.2012.04.009

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