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首页> 外文期刊>Vaccine >Avian paramyxovirus serotypes 2-9 (APMV-2-9) vary in the ability to induce protective immunity in chickens against challenge with virulent Newcastle disease virus (APMV-1).
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Avian paramyxovirus serotypes 2-9 (APMV-2-9) vary in the ability to induce protective immunity in chickens against challenge with virulent Newcastle disease virus (APMV-1).

机译：禽副粘病毒血清型2-9（APMV-2-9）在诱导鸡抵抗强毒新城疫病毒（APMV-1）攻击的保护性免疫能力方面有所不同。

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The avian paramyxoviruses (APMVs) belong to the genus Avulavirus of family Paramyxoviridae. The APMVs are classified into nine serotypes on the basis of hemagglutination inhibition (HI) and neuraminidase inhibition (NI) assays, although some serologic cross-reaction exists. Newcastle disease virus (NDV), which constitutes serotype 1 (APMV-1), is an important pathogen of poultry, but the pathogenic potential of the other APMV serotypes is poorly understood. Although antibodies to APMV-2 to -9 are prevalent in chickens, the effect of prior exposure to these serotypes on susceptibility to NDV infection and disease was not known. In the present study, chickens were immunized with APMV-2 to -9 by the oculo-nasal route and later were challenged by the same route with a highly virulent strain of NDV. Among APMV-2 to -9, only APMV-3 induced serum antibodies that cross-reacted significantly with NDV and had significant NDV-neutralizing activity in vitro. In mock-immunized chickens, challenge NDV replicated throughout the respiratory tract as well as in the brain, spleen, and enteric tract. In contrast, in APMV-3-immunized chickens, challenge NDV replication was restricted to the upper respiratory tract and trachea. Some of the other APMVs also induced partial restriction of challenge NDV replication: for example, challenge NDV was not detected in the brains of APMV-9-immunized chickens, and shedding from the respiratory tract was reduced in chickens immunized with APMV-8 and -9. All of the chickens immunized with APMV-3 survived the NDV challenge; with APMV-2, -7, -8, and -9 the percentage survival was 30%, 20%, 20%, and 52.5%, respectively; whereas none of the chickens immunized with APMV-4, -5, or -6 survived. These results show that prior infection of chickens with APMV-3 induced substantial protection against NDV challenge, whereas prior infection with APMV-2, -7, -8, and -9 can alter subsequent NDV infection. The induction of NDV-neutralizing antibodies was a marker for efficient protection, but partial protection also was observed in their absence.
机译：禽副粘病毒（APMVs）属于副粘病毒科的肺炎病毒。尽管存在一些血清学交叉反应，但根据血细胞凝集抑制（HI）和神经氨酸酶抑制（NI）分析，APMV分为9种血清型。构成血清型1（APMV-1）的新城疫病毒（NDV）是家禽的重要病原体，但对其他APMV血清型的致病潜力却知之甚少。尽管针对APMV-2至-9的抗体在鸡中普遍存在，但事先暴露于这些血清型对NDV感染和疾病的敏感性尚不清楚。在本研究中，通过眼鼻途径将鸡用APMV-2免疫至-9，然后用高毒力的NDV菌株以相同的途径攻击鸡。在APMV-2至-9中，只有APMV-3诱导的血清抗体与NDV显着交叉反应，并且在体外具有显着的NDV中和活性。在模拟免疫的鸡中，挑战性NDV在整个呼吸道以及大脑，脾脏和肠道均复制。相反，在经APMV-3免疫的鸡中，挑战性NDV复制仅限于上呼吸道和气管。其他一些APMV也诱导了挑战性NDV复制的部分限制：例如，在用APMV-9免疫的鸡的大脑中未检测到挑战性NDV，用APMV-8免疫的鸡减少了呼吸道脱落，并且- 9。用APMV-3免疫的所有鸡都在NDV攻击中幸存下来。使用APMV-2，-7，-8和-9时，存活率分别为30％，20％，20％和52.5％;而用APMV-4，-5或-6免疫的鸡都没有存活。这些结果表明，先前用APMV-3感染鸡对NDV攻击具有实质性的保护作用，而先前用APMV-2，-7，-8和-9感染可改变随后的NDV感染。 NDV中和抗体的诱导是有效保护的标志，但是在不存在它们的情况下也观察到部分保护。

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