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Seroepidemiology of hepatitis B virus infection among adults in Singapore: A 12-year review

机译:新加坡成年人中乙型肝炎病毒感染的血清流行病学:一项为期12年的回顾

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We undertook a national hepatitis B seroprevalence study to assess the seroprevalence of hepatitis B virus (HBV) markers in the adult population in Singapore in 2010 and make comparisons with the seroprevalence in 1998 and 2004. The study involved residual sera from national health surveys conducted every six years since 1998. The tests for HBV markers were carried out using commercial chemiluminescent microparticle immunoassay. In 2010, the prevalence of hepatitis B surface antigen (HBsAg) among 3293 Singapore residents aged 18-79 years was 3.6% (95% confidence interval [Cl] 2.9-4.2%). Hepatitis Be antigen (HBeAg) was detected in 4.2% of those who were HBsAg positive. About 22.5% (95% CI 21.1-23.9%) were positive for antibody to hepatitis B core antigen (anti-HBc). The overall population immunity to HBV, as determined by antibody to hepatitis B surface antigen (anti-HBs) >= 10 mIU/mL, was 43.9% (95% CI 42.2-45.6%). Among young adults below 30 years of age, HBsAg prevalence (1.1%) was half that in 1998 and 2004, and in those positive for HBsAg, none was positive for HBeAg in 2010, compared to 20.8% in 1998 and 15.8% in 2004. In this age group, anti-HBc prevalence also decreased significantly from 22.1% in 2004 to 4.4% in 2010, while anti-HBs (>= 10 mIU/mL) prevalence increased significantly from 27.9% in 1998 to 43.3% in 2010 (p < 0.001). The national childhood HBV immunisation and catch-up programmes implemented in 1987 and 2001-2004, respectively, had a significant impact in reducing HBV infection and in raising the immunity of the adult population 18-29 years of age
机译:我们进行了一项全国性的乙型肝炎血清学研究,以评估2010年新加坡成年人口中的乙型肝炎病毒血清学标志物,并与1998年和2004年的血清学流行病进行比较。该研究涉及每次国家卫生调查中的残留血清自1998年以来的6年。HBV标志物的测试使用商业化学发光微粒免疫测定法进行。 2010年,在3293名18-79岁的新加坡居民中,乙型肝炎表面抗原(HBsAg)的患病率为3.6%(95%置信区间[Cl]为2.9-4.2%)。在HBsAg阳性的患者中有4.2%检出了Be Be肝抗原(HBeAg)。约22.5%(95%CI 21.1-23.9%)的乙型肝炎核心抗原(anti-HBc)抗体呈阳性。由抗乙肝表面抗原(抗-HBs)> = 10 mIU / mL的抗体确定的总体人群对HBV的免疫力为43.9%(95%CI 42.2-45.6%)。在30岁以下的年轻人中,HBsAg的患病率(1.1%)是1998年和2004年的一半,而HBsAg阳性的人中,HBeAg的阳性率在2010年没有,而1998年和2005年分别为20.8%和15.8%。在这个年龄段,抗HBc患病率也从2004年的22.1%显着下降到2010年的4.4%,而抗HBs(> = 10 mIU / mL)患病率从1998年的27.9%显着增加到2010年的43.3%(p <0.001)。分别于1987年和2001-2004年实施的全国儿童HBV免疫和追赶计划对减少HBV感染和提高18-29岁成年人口的免疫力具有重大影响

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