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首页> 外文期刊>Vaccine >Comparison of CRM sub 197 /sub , diphtheria toxoid and tetanus toxoid as protein carriers for meningococcal glycoconjugate vaccines.
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Comparison of CRM sub 197 /sub , diphtheria toxoid and tetanus toxoid as protein carriers for meningococcal glycoconjugate vaccines.

机译：CRM 197 ，白喉类毒素和破伤风类毒素作为脑膜炎球菌糖缀合物疫苗的蛋白载体的比较。

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Glycoconjugate vaccines are among the most effective and safest vaccines ever developed. Diphtheria toxoid (DT), tetanus toxoid (TT) and CRM197 have been mostly used as protein carriers in licensed vaccines. We evaluated the immunogenicity of serogroup A, C, W-135 and Y meningococcal oligosaccharides conjugated to CRM197, DT and TT in naive mice. The three carriers were equally efficient in inducing an immune response against the carbohydrate moiety in immunologically naive mice. The effect of previous exposure to different dosages of the carrier protein on the anti-carbohydrate response was studied using serogroup A meningococcal (MenA) saccharide conjugates as a model. CRM197 showed a strong propensity to positively prime the anti-carbohydrate response elicited by its conjugates or those with the antigenically related carrier DT. Conversely in any of the tested conditions TT priming did not result in enhancement of the anti-carbohydrate response elicited by the corresponding conjugates. Repeated exposure of mice to TT or to CRM197 before immunization with the respective MenA conjugates resulted in a drastic suppression of the anti-carbohydrate response in the case of TT conjugate and only in a slight reduction in the case of CRM197. The effect of carrier priming on the anti-MenA response of DT-based conjugates varied depending on their carbohydrate to protein ratio. These data may have implications for human vaccination since conjugate vaccines are widely used in individuals previously immunized with DT and TT carrier proteins.Digital Object Identifier http://dx.doi.org/10.1016/j.vaccine.2013.07.078
机译：糖缀合物疫苗是有史以来最有效和最安全的疫苗之一。白喉类毒素（DT），破伤风类毒素（TT）和CRM 197 被广泛用作许可疫苗中的蛋白质载体。我们评估了天真小鼠中与CRM 197 ，DT和TT结合的A，C，W-135和Y型脑膜炎球菌血清群的免疫原性。这三种载体在免疫学上天然的小鼠中诱导针对碳水化合物部分的免疫应答同样有效。使用血清群A脑膜炎球菌（MenA）糖缀合物作为模型，研究了先前暴露于不同剂量的载体蛋白对抗碳水化合物反应的影响。 CRM 197 显示出强烈的倾向，可以积极引发其结合物或与抗原相关载体DT结合的抗碳水化合物反应。相反，在任何测试条件下，TT引发都不会导致相应缀合物引发的抗碳水化合物反应增强。在用相应的MenA结合物免疫之前，小鼠反复暴露于TT或CRM 197 会严重抑制抗碳水化合物反应（在TT结合物的情况下），但只会稍微降低CRM 197 。载体引发对基于DT的结合物抗MenA反应的影响取决于其碳水化合物与蛋白质的比例。这些数据可能对人类疫苗接种有影响，因为结合疫苗已广泛用于先前用DT和TT载体蛋白免疫的个体中。数字对象标识符http://dx.doi.org/10.1016/j.vaccine.2013.07.078

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