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Estimates of the annual direct medical costs of the prevention and treatment of disease associated with human papillomavirus in the United States

机译：在美国预防和治疗与人乳头瘤病毒相关疾病的年度直接医疗费用的估算

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摘要

Estimates of the direct medical costs attributable to human papillomavirus (HPV) can help to quantify the economic burden of HPV and to illustrate the potential benefits of HPV vaccination. The purpose of this report was to update the estimated annual direct medical costs of the prevention and treatment of HPV-associated disease in the United States, for all HPV types. We included the costs of cervical cancer screening and follow-up and the treatment costs of the following HPV-associated health outcomes: cervical cancer, other anogenital cancers (anal, vaginal, vulvar and penile), oropharyngeal cancer, genital warts, and recurrent respiratory papillomatosis (RRP). We obtained updated incidence and cost estimates from the literature. The overall annual direct medical cost burden of preventing and treating HPV-associated disease was estimated to be $8.0 billion (2010 U.S. dollars). Of this total cost, about $6.6 billion (82.3%) was for routine cervical cancer screening and follow-up, $1.0 billion (12.0%) was for cancer (including $0.4 billion for cervical cancer and $0.3 billion for oropharyngeal cancer), $0.3 billion (3.6%) was for genital warts, and $0.2 billion (2.1%) was for RRP.
机译：归因于人乳头瘤病毒（HPV）的直接医疗费用的估算可以帮助量化HPV的经济负担，并说明HPV疫苗接种的潜在好处。本报告的目的是更新所有HPV类型在美国预防和治疗HPV相关疾病的估计年度直接医疗费用。我们包括了子宫颈癌筛查和随访的费用以及以下与HPV相关的健康结果的治疗费用：子宫颈癌，其他肛门生殖器癌（肛门，阴道，外阴和阴茎），口咽癌，生殖器疣和复发性呼吸道疾病乳头状瘤病（RRP）。我们从文献中获得了更新的发病率和成本估算。预防和治疗HPV相关疾病的年度总直接医疗费用负担估计为80亿美元（2010年美元）。在总费用中，约66亿美元（82.3％）用于常规子宫颈癌筛查和随访，10亿美元（12.0％）用于癌症（包括4亿美元用于宫颈癌和3亿美元用于口咽癌），3亿美元（生殖器疣占3.6％，RRP占2亿美元（2.1％）。

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