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首页> 外文期刊>Vaccine >Antibody persistence of two pentavalent DTwP-HB-Hib vaccines to the age of 15-18 months, and response to the booster dose of quadrivalent DTwP-Hib vaccine.
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Antibody persistence of two pentavalent DTwP-HB-Hib vaccines to the age of 15-18 months, and response to the booster dose of quadrivalent DTwP-Hib vaccine.

机译：两种五价DTwP-HB-Hib疫苗的抗体持久性为15至18个月大，并对四价DTwP-Hib疫苗的加强剂量有反应。

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Objectives: Antibody persistence in children following three doses of primary vaccination with diphtheria, tetanus, whole-cell-pertussis (DTwP), hepatitis B, and Haemophilus influenzae type b (Hib) vaccines (SIIL Pentavac vaccine vs. Easyfive of Panacea Biotec), and response to the booster dose of DTwP-Hib (Quadrovax) vaccine. Methods: Children who completed their primary immunization were assessed for antibodies at 15-18 months of age, and then given a booster dose of DTwP-Hib vaccine. Reactogenicity and safety of the booster dose was evaluated. Results: Both pentavalent vaccines demonstrated a good immune response at 15-18 months. Following the booster dose, all vaccinated subjects achieved protective titers against diphtheria, tetanus and Hib, whereas the response to pertussis antigen was ~78%. Fever and irritability was noted in 24%, local pain in 51%, and swelling in 36% of the children following booster dose. Conclusions: Primary immunization with either pentavalent vaccine induced an excellent immunity lasting till the second year of life. A booster dose with DTwP-Hib (Quadrovax) vaccine effectuated a good anamnestic response to all vaccine components, being specially strong for Hib in children previously vaccinated with SIIL liquid pentavalent vaccine (Pentavac). Also, the safety profile of SIIL quadrivalent vaccine (Quadrovax) administered as booster dose was acceptable.
机译：目的：对白喉，破伤风，全细胞百日咳（DTwP），乙型肝炎和乙型流感嗜血杆菌疫苗（SIIL Pentavac疫苗与Panacea Biotec的Easyfive疫苗）进行三剂初次接种后，儿童的抗体持久性，和对DTwP-Hib（Quadrovax）疫苗加强剂量的反应。方法：对完成初次免疫的儿童在15-18个月大时进行抗体评估，然后给予加强剂量的DTwP-Hib疫苗。评估了加强剂量的反应原性和安全性。结果：两种五价疫苗在15-18个月时均表现出良好的免疫反应。加强剂量后，所有接种疫苗的受试者均获得了针对白喉，破伤风和Hib的保护性滴度，而对百日咳抗原的反应为〜78％。加强剂量后有24％的儿童出现发烧和烦躁，局部疼痛为51％，有36％出现肿胀。结论：两种五价疫苗的初次免疫都可产生良好的免疫力，持续到生命的第二年。 DTwP-Hib（Quadrovax）疫苗的加强剂量对所有疫苗成分均具有良好的记忆消除效果，对于以前接种过SIIL五价液疫苗（Pentavac）的儿童中的Hib尤其强。同样，以加强剂量施用的SIIL四价疫苗（四联疫苗）的安全性也可以接受。

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