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首页> 外文期刊>Vaccine >Sustained functional serotype-specific antibody after primary and secondary vaccinations with a pneumococcal polysaccharide vaccine in elderly patients with chronic lung disease
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Sustained functional serotype-specific antibody after primary and secondary vaccinations with a pneumococcal polysaccharide vaccine in elderly patients with chronic lung disease

机译：老年肺病患者初次和二次接种肺炎球菌多糖疫苗后持续血清功能特异性抗体

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An observational study was conducted to determine immunogenicity before and after primary and secondary vaccinations with 23-valent pneumococcal polysaccharide vaccine in a cohort of 40 elderly patients with chronic lung diseases. Safety of this vaccine was also compared between primary and secondary vaccination. We analyzed serotype-specific immunoglobulin G (IgG) and the opsonization index (OI) for serotypes 6B, 14, 19F, and 23F and compared adverse local and systemic reactions. The levels of serotype-specific IgG and the OIs significantly increased 1 month after primary and secondary vaccinations. Peak levels of IgG after secondary vaccination were 5-20% lower than those after primary vaccination, while serotype-specific Is after secondary vaccination were comparable with those after primary vaccination. The levels of serotype-specific IgG required for 50% killing significantly decreased 1 month after vaccination. These values for serotypes 14, 19F, and 23F were slightly elevated immediately before secondary vaccination, but those for serotype 6B did not change. After secondary vaccination, these values declined slightly for serotypes 14, 19F, and 23F and remained low for serotype 6B. Although self-limited local and systemic reactions were more frequent after secondary vaccination compared with primary vaccination, no serious systemic reaction was found after either vaccination. Our data suggest a sustained functional serotype-specific IgG after primary and secondary vaccination and confirmed the safety of secondary vaccination among elderly individuals with chronic lung disease
机译：进行了一项观察性研究，以确定在40名老年慢性肺病患者队列中，初次和二次疫苗接种23价肺炎球菌多糖疫苗前后的免疫原性。还比较了初次和二次接种之间该疫苗的安全性。我们分析了血清型特异性免疫球蛋白G（IgG）和血清型6B，14、19F和23F的调理作用指数（OI），并比较了局部和全身不良反应。初次和二次疫苗接种后1个月，血清型特异性IgG和OI的水平显着增加。二次疫苗接种后的IgG峰值水平比初次接种疫苗后低5-20％，而二次接种后的血清型特异性Is与初次接种后相当。接种后1个月，杀死50％所需的血清型特异性IgG的水平明显降低。对于血清型14、19F和23F，在刚进行二次疫苗接种之前，这些值略有升高，但是对于血清型6B，这些值没有变化。二次接种后，血清型14、19F和23F的这些值略有下降，血清型6B的这些值仍然很低。尽管与初次接种相比，二次接种后自我限制的局部和全身反应更为频繁，但在两次接种后均未发现严重的全身反应。我们的数据表明，初次和二次疫苗接种后可持续的功能血清型特异性IgG，并证实了慢性肺病老年患者二次接种的安全性

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