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首页> 外文期刊>Vaccine >Detection of Clostridium sordellii strains expressing hemorrhagic toxin (TcsH) and implications for diagnostics and regulation of veterinary vaccines
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Detection of Clostridium sordellii strains expressing hemorrhagic toxin (TcsH) and implications for diagnostics and regulation of veterinary vaccines

机译：检测表达出血性毒素（TcsH）的梭状芽胞杆菌菌株及其对兽医疫苗的诊断和调节的意义

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Clostridium sordellii is a Gram positive anaerobic bacterium that causes multiple disease syndromes in both humans and animals. As with many clostridial pathogens, toxins contribute to the virulence of C. sordellii. Two large toxins have been identified: a lethal toxin (TcsL) and a hemorrhagic toxin (TcsH) which are similar in structure and function to Clostridium difficile toxin B (TcdB) and toxin A (TcdA), respectively. While TcdA,TcdB, and TcsL have been extensively studied, relatively little is known about TcsH. This study elucidated the TcsH gene sequence using whole genome sequencing, compared the genotype with toxin expression of 52 C. sordellii strains, and examined the role of TcsH in batch release potency tests required for veterinary vaccines licensed in the United States and other testing utilizing WHO standard antitoxin. Data from this study will assist in future research to clarify the TcsH contribution to the pathogenesis of C sordellii infections and may aid in the development of improved vaccines. Published by Elsevier Ltd.
机译：梭菌梭状芽胞杆菌是一种革兰氏阳性厌氧细菌，可在人类和动物中引起多种疾病。与许多梭菌病原体一样，毒素会导致索氏梭菌的毒性增加。已鉴定出两种大毒素：致死性毒素（TcsL）和出血性毒素（TcsH），其结构和功能分别与艰难梭菌毒素B（TcdB）和毒素A（TcdA）相似。尽管已经对TcdA，TcdB和TcsL进行了广泛研究，但对TcsH的了解相对较少。这项研究使用全基因组测序阐明了TcsH基因序列，比较了52种Sodellii菌株的基因型和毒素表达，并研究了TcsH在美国许可的兽用疫苗所需的分批释放效力测试中的作用以及其他利用WHO的测试标准抗毒素。来自这项研究的数据将有助于未来的研究，以阐明TcsH对Sodellii感染的发病机理的贡献，并可能有助于开发改进的疫苗。由Elsevier Ltd.发布

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