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首页> 外文期刊>Vaccine >Effectiveness of influenza vaccination in elderly diabetic patients: A retrospective cohort study
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Effectiveness of influenza vaccination in elderly diabetic patients: A retrospective cohort study

机译：老年糖尿病患者流感疫苗接种的有效性：一项回顾性队列研究

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Purpose: Studies regarding the clinical benefits of influenza vaccination in diabetic patients are limited. This study evaluated if the elderly diabetic patients who have had influenza vaccination would have benefits such as reduced medical care and mortality. Methods: We used the universal insurance claims data from 2001 to 2009 in Taiwan to identify annual elderly patients with diabetes cohorts with (N=4454) and without (N=4571) influenza vaccination. The risk of developing pneumonia or influenza,respiratory failure, intensive care, hospitalization, and mortality were measured and compared between cohorts within one year of follow-up. Results: The vaccine cohort had lower incidences of pneumonia or influenza and respiratory failure compared withthe non-vaccine cohort. More importantly, the vaccine cohort had a hospitalization rate that was 11% less than the non-vaccine cohort (29.6 vs. 33.1 per 100 person-years) with an adjusted hazard ratio (HR) of0.88 (95% Cl 0.81-0.96). The vaccine cohort was also less likely to be admitted to the intensive care unit (ICU) [0.58 vs. 2.05 per 100 person-year; adjusted HR 0.30 (95% Cl 0.19-0.47)] and less likely to expire [3.13 vs. 7.96 per 100 person-year; adjusted HR 0.44 (95% Cl 0.36-0.54)]. Influenza vaccination reduced the hospitalization cost by 1282.6 USD, compared with patients without influenza vaccination (95% Cl -2210.3, -354.8). Conclusion: Influenza vaccination is associated with a reduced risk of morbidity, hospitalization, ICU admissions, andmortality. In addition, the hospitalization cost is reduced.
机译：目的：关于在糖尿病患者中接种流感疫苗的临床益处的研究有限。这项研究评估了接受流感疫苗接种的老年糖尿病患者是否会受益，例如减少医疗护理和降低死亡率。方法：我们使用2001年至2009年台湾的万能保险理赔数据，确定了每年有（N = 4454）和没有（N = 4571）流感疫苗接种的糖尿病队列的老年患者。在随访的一年内，测量并比较了队列中发生肺炎或流感的风险，呼吸衰竭，重症监护，住院和死亡率。结果：与非疫苗组相比，疫苗组的肺炎或流感和呼吸衰竭发生率较低。更重要的是，疫苗队列的住院率比非疫苗队列低11％（每100人年29.6比33.1），调整后的危险比（HR）为0.88（95％Cl 0.81-0.96） ）。重症监护病房（ICU）也不太可能接受疫苗队列[每100人年0.58比2.05;调整后的HR 0.30（95％Cl 0.19-0.47），并且不太可能过期[每100人年3.13比7.96;调整后的HR 0.44（95％Cl 0.36-0.54）]。与未接种流感疫苗的患者相比，接种流感疫苗使住院费用减少了1282.6美元（95％Cl -2210.3，-354.8）。结论：流感疫苗接种与降低发病率，住院，重症监护病房入院和死亡的风险有关。另外，降低了住院费用。

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