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首页> 外文期刊>Vaccine >Identification of a surface protective antigen, CSP of Streptococcus equi ssp. zooepidemicus.
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Identification of a surface protective antigen, CSP of Streptococcus equi ssp. zooepidemicus.

机译：鉴定表面保护性抗原，马链球菌ssp的CSP。兽疫。

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Streptococcus equi ssp. zooepidemicus (Streptococcus zooepidemicus, SEZ) is an important pathogen associated with opportunistic infections of a wide range of species, including horses, pigs and humans. The absence of suitable vaccine confounds the control of SEZ infection. Cell surface protein (CSP) has been identified as an immunogenic protein in the previous study but its protective efficacy is not clear. In the present study, the purified recombinant CSP could elicit a significant humoral antibody response and could confer significant protection against challenge with lethal dose of SEZ in mice model. CSP could adhere to the HEp-2 cells confirmed by flow cytometry and inhibit adherence of SEZ to HEp-2 cells in an adherence inhibition assay. In addition, real-time PCR demonstrated that CSP was induced in vivo following infection of mice with SEZ. Our findings suggest that CSP may play a potential role in the pathogenesis of SEZ and could be a target for the development of a novel subunit vaccine against SEZ infection.Digital Object Identifier http://dx.doi.org/10.1016/j.vaccine.2012.12.079
机译：马链球菌人兽共患病（Streptococcus zooepidemicus，SEZ）是一种重要的病原体，与马，猪和人等多种物种的机会性感染有关。没有合适的疫苗会混淆对SEZ感染的控制。细胞表面蛋白（CSP）在先前的研究中已被鉴定为免疫原性蛋白，但其保护功效尚不清楚。在本研究中，纯化的重组CSP可以引起显着的体液抗体反应，并且可以在小鼠模型中针对致命剂量的SEZ给予有效的保护，使其免受攻击。 CSP可以粘附到流式细胞仪确认的HEp-2细胞上，并在粘附抑制试验中抑制SEZ对HEp-2细胞的粘附。此外，实时PCR证明，在用SEZ感​​染小鼠后，体内可诱导CSP。我们的发现表明，CSP可能在SEZ的发病机理中发挥潜在作用，并可能成为开发针对SEZ感染的新型亚单位疫苗的目标。数字对象标识符http://dx.doi.org/10.1016/j.vaccine .2012.12.079

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