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首页> 外文期刊>Vaccine >Irregular tick-borne encephalitis vaccination schedules: the effect of a single catch-up vaccination with FSME-IMMUN. a prospective non-interventional study.
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Irregular tick-borne encephalitis vaccination schedules: the effect of a single catch-up vaccination with FSME-IMMUN. a prospective non-interventional study.

机译：tick传播的不规则脑炎疫苗接种时间表：FSME-IMMUN单次追赶疫苗接种的效果。前瞻性非干预性研究。

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Background: Intervals longer than recommended are frequently encountered between doses of tick borne encephalitis virus (TBE) vaccines in both residents of and travelers to endemic regions. In clinical practice the management of individuals with lapsed TBE vaccination schedules varies widely and has in common that the underlying immunological evidence is scarce. Study purpose and methods The aim of this study was to generate data reliable enough to derive practical recommendations on how to continue vaccination with FSME-IMMUN in subjects with an irregular TBE vaccination history. Antibody response to a single catch-up dose of FSME-IMMUN was assessed in 1115 adults (age >=16 years) and 125 children (age 6-15 years) with irregular TBE vaccination histories. Results: Subjects of all age groups developed a substantial increase in geometric mean antibody concentration after a single catch-up TBE vaccination which was consistently lower in subjects with only one previous TBE vaccination compared to subjects with two or more vaccinations. Overall, >94% of young adults and children, and >93% of elderly subjects with an irregular TBE vaccination history achieved antibody levels >=25 U/ml irrespective of the number of previous TBE vaccinations. Conclusion: We conclude that TBE vaccination of subjects with irregular vaccination histories should be continued as if the previous vaccinations had been administered in a regular manner, with the stage of the vaccination schedule being determined by the number of previous vaccinations. Although lapsed vaccination schedules may leave subjects temporarily with inadequate protection against TBE infection, adequate protection can quickly be re-established in >93% of the subjects by a single catch-up dose of FSME-IMMUN, irrespective of age, number of previous vaccinations, and time interval since the last vaccination.
机译：背景：在流行地区的居民和旅行者中，两次tick传播性脑炎病毒（TBE）疫苗的剂量间隔经常比建议的更长。在临床实践中，对TBE疫苗接种计划已过期的个体的管理差异很大，并且共同之处在于缺乏基本的免疫学证据。研究目的和方法这项研究的目的是生成足够可靠的数据，以得出有关如何在TBE疫苗接种史不规律的受试者中继续进行FSME-IMMUN疫苗接种的实用建议。在1115名成年人（≥16岁）和125名儿童（6至15岁）具有不定期的TBE疫苗接种史的情况下，评估了其对单次补充FSME-IMMUN的抗体反应。结果：所有年龄组的受试者在单次追赶TBE疫苗接种后均出现几何平均抗体浓度的大幅增加，与仅进行两次或多次接种的受试者相比，以前仅接种过一次TBE疫苗的受试者始终较低。总体而言，≥94％的年轻人和儿童，以及> 93％的具有不规则TBE疫苗接种史的老年受试者达到的抗体水平> = 25 U / ml，与先前的TBE疫苗接种次数无关。结论：我们得出结论，应继续对有不定期疫苗接种历史记录的受试者进行TBE疫苗接种，就像以前的疫苗接种是按常规方式进行的一样，接种时间表的阶段取决于以前的疫苗接种次数。尽管疫苗接种时间安排已过久，可能会使受试者暂时无法获得足够的针对TBE感染的防护，但是，无论年龄，既往疫苗接种的次数，是否接受FSME-IMMUN的单一补充剂量，都能迅速在超过93％的受试者中重新建立足够的防护。 ，以及自上次接种疫苗以来的时间间隔。

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