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Vaccine administration in children with chronic kidney disease

机译：慢性肾脏病患儿的疫苗接种

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Pediatric patients with severe chronic kidney disease (CKD) on conservative treatment, on dialysis, and those with renal transplantation are at a higher risk for infectious diseases as the result of impaired immune responses against infectious agents. Infections in these patients can have drastic consequences for disease morbidity and mortality. Immunization is a crucial preventive strategy for disease management in this pediatric population. However, vaccination coverage among children with CKD remains low due to safety concerns and doubts about vaccine immunogenicity and efficacy. In this study, we reviewed why children with CKD are at higher risk of infections, the importance of vaccinations among these children, barriers to vaccinations, and recommend the best vaccination schedules. Overall, vaccines have acceptable immunogenicity, efficacy, and safety profiles in children with CKD. However, in some cases, the protective antibody levels induced by vaccines and the benefits and risks of booster vaccine doses must be individually managed. Furthermore, close contacts and household members of these children should complete age-appropriate vaccination schedules to increase the child's indirect protection. (C) 2014 Elsevier Ltd. All rights reserved.
机译：保守治疗，透析治疗的严重慢性肾脏病（CKD）小儿患者和肾移植患者由于对传染原免疫反应受损而感染传染病的风险更高。这些患者中的感染可能会对疾病的发病率和死亡率产生严重影响。免疫是该儿童人群疾病管理的重要预防策略。然而，由于对安全性的担忧以及对疫苗免疫原性和功效的怀疑，CKD儿童的疫苗接种率仍然很低。在这项研究中，我们回顾了为什么患有CKD的儿童有较高的感染风险，这些儿童中接种疫苗的重要性，接种疫苗的障碍，并建议了最佳的接种时间表。总体而言，疫苗对CKD儿童具有可接受的免疫原性，功效和安全性。但是，在某些情况下，必须单独管理疫苗诱导的保护性抗体水平以及加强疫苗剂量的益处和风险。此外，这些孩子的亲密接触者和家庭成员应完成适合年龄的疫苗接种计划，以增加对孩子的间接保护。 （C）2014 Elsevier Ltd.保留所有权利。

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