Challenges in vaccination of neonates, infants and young children

Pichichero Michael E.

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Challenges in vaccination of neonates, infants and young children

机译：新生儿，婴儿和幼儿的疫苗接种挑战

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All neonates, infants and young children receive multiple priming doses and booster vaccinations in the 1st and 2nd year of life to prevent infections by viral and bacterial pathogens. Despite high vaccine compliance, outbreaks of vaccine-preventable infections are occurring worldwide. These data strongly argue for an improved understanding of the immune responses of neonates, infants and young children to vaccine antigens and further study of the exploitable mechanisms to achieve more robust and prolonged immunity with fewer primary and booster vaccinations in the pediatric population. This review will focus on our recent work involving infant and young child immunity following routine recommended vaccinations. The discussion will address vaccine responses with respect to four areas: (1) systemic antibody responses, (2) memory B-cell generation, (3) CD4 T-cell responses, and (4) APC function

机译：所有新生儿，婴幼儿在生命的第一和第二年均接受多次初免剂量和加强疫苗接种，以防止被病毒和细菌病原体感染。尽管对疫苗的依从性很高，但世界各地仍在爆发疫苗可预防的感染。这些数据强烈要求对新生儿，婴儿和幼儿对疫苗抗原的免疫反应有更好的了解，并进一步研究可利用的机制，以在儿科人群中较少的初次和加强接种情况下获得更强大和更长的免疫力。这篇综述将重点关注我们最近进行的常规接种疫苗后涉及的婴幼儿免疫力的工作。讨论将针对以下四个方面讨论疫苗反应：（1）全身性抗体反应，（2）记忆B细胞生成，（3）CD4 T细胞反应和（4）APC功能

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《Vaccine》 |2014年第31期|共9页
作者
Pichichero Michael E.;
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Vaccination; Neonate; Infants; Children; B cells; T cells; Antigen presenting cells; Dendritic cells; immunologic memory; pediatric vaccines; Streptococcus pneumoniae; Haemophilus influenzae; B-cell receptor; MHC II; CD4 T-cells; cytokines; T-cell receptor; Toll-like receptor;

机译：疫苗;新生儿;婴儿;儿童;B细胞;T细胞;抗原呈递细胞;树突状细胞;免疫记忆;儿科疫苗;肺炎链球菌;流感嗜血杆菌;B细胞受体;MHC II;CD4 T细胞;细胞因子;T-细胞受体;Toll样受体;

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1. Challenges in vaccination of neonates, infants and young children [J] . Pichichero Michael E. Vaccine . 2014,第31期

机译：新生儿，婴儿和幼儿的疫苗接种挑战
2. Nonspecific effects of neonatal and infant vaccination: public-health, immunological and conceptual challenges. [J] . Peter Aaby, Tobias R Kollmann, Christine Stabell Benn Nature immunology . 2014,第10期

机译：新生儿和婴儿疫苗接种的非特异性影响：公共卫生，免疫和概念挑战。
3. Nonspecific effects of neonatal and infant vaccination: public-health, immunological and conceptual challenges. [J] . Peter Aaby, Tobias R Kollmann, Christine Stabell Benn Nature immunology . 2014,第10期

机译：新生儿和婴儿疫苗接种的非特异性影响：公共卫生，免疫学和概念挑战。
4. The Future of Infant and Young Children's Food: Food Supply/ Manufacturing and Human Health Challenges in the 21st Century [C] . Carina Venter, Kate Maslin Nestlé Nutrition Institute Workshop . 2016

机译：婴儿和幼儿食品的未来：21世纪的食品供应/制造业和人类健康挑战
5. Impact of maternal Tdap vaccination on pertussis infection in young infants. [D] . Castagnini Castro, Luis Antonio. 2010

机译：母体Tdap疫苗接种对幼儿百日咳感染的影响。
6. Challenges in Vaccination of Neonates Infants and Young Children [O] . Michael E. Pichichero -1

机译：新生儿婴儿和幼儿的疫苗接种挑战
7. Challenges in vaccination of neonates, infants and young children [O] . Michael E. Pichichero 2014

机译：新生儿，婴儿和幼儿疫苗接种的挑战

Challenges in vaccination of neonates, infants and young children

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