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首页> 外文期刊>Vaccine >Inpatient admission for febrile seizure and subsequent outcomes do not differ in children with vaccine-associated versus non-vaccine associated febrile seizures
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Inpatient admission for febrile seizure and subsequent outcomes do not differ in children with vaccine-associated versus non-vaccine associated febrile seizures

机译：疫苗相关性和非疫苗相关性热性惊厥患儿的高热惊厥住院治疗和随后的结局无差异

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Introduction: Recent data suggest that the risk factors for febrile seizure (FS) can differ depending on whether the FS was vaccine-associated (VA) or not. As such, there also may be differences in the risk of inpatient admission and/or the incidence of FS-related subsequent outcomes following the index FS depending on whether it was VA or non-vaccine associated (NVA). This could have useful clinical implications including caregiver education and planning for follow-up care. Methods: This cohort study consisted of 3348 children who experienced an index FS between 6 months up to 3 years of age from July 1, 2003 through December 31, 2011. The index FS was determined to be VA-FS or NVA-FS; inpatient admission for FS, recurrent FS, and diagnosis of epilepsy were compared between exposure groups. Hazard ratios and relative risk estimates comparing between VA-FS and NVA-FS were estimated by Cox proportional models and Robust Poisson regression models, adjusted for race, sex, age at first FS, birth weight, gestational age, maternal age, and 1- and 5-min Apgar scores. Results: The mean age at index FS was 1.5 years; the mean length of follow-up was 2.3 years. Of all index FS, 383 (11.4%) were VA and 2965 were NVA. Among index FS, 264(7.9%) were admitted as inpatients. Subsequently, 703 (21.0%) children developed at least one recurrent FS, where the number of recurrences ranged from 0 to 9 events. Overall, 144(4.3%) children were diagnosed with epilepsy during the follow-up period. In adjusted analyses, VA-FS did not differ in the risk for any of the outcomes of interest compared with NVA-FS. Discussion: The risk of hospitalization for index FS or select subsequent FS outcomes did not differ between VA or NVA-FS. This suggests that the follow-up care of children with VA-FS does not warrant attention beyond that for NVA-FS. (C) 2014 Elsevier Ltd. All rights reserved.
机译：简介：最新数据表明，高热惊厥（FS）的危险因素可能有所不同，具体取决于FS是否与疫苗相关（VA）。因此，根据FS指数，其住院率和/或与FS相关的后续结局的发生率也可能存在差异，具体取决于是VA还是非疫苗相关（NVA）。这可能具有有用的临床意义，包括护理人员教育和后续护理计划。方法：该队列研究由3348名儿童组成，他们从2003年7月1日至2011年12月31日在6个月至3岁之间经历了FS指数。FS指数被确定为VA-FS或NVA-FS。比较暴露组之间住院的FS，FS复发和癫痫的诊断。通过Cox比例模型和Robust Poisson回归模型估算了VA-FS和NVA-FS之间的危险比和相对风险估计，并根据种族，性别，首次FS的年龄，出生体重，胎龄，产妇年龄和1-和5分钟的Apgar得分。结果：FS指数的平均年龄为1.5岁。平均随访时间为2.3年。在所有FS指标中，VA为383（11.4％），NVA为2965。在FS指数中，有264例（7.9％）是住院病人。随后，703名（21.0％）儿童发展出至少一个复发性FS，其中复发次数为0至9个事件。总体而言，在随访期间有144名（4.3％）儿童被诊断出患有癫痫病。在调整后的分析中，与NVA-FS相比，VA-FS的任何感兴趣结局的风险均无差异。讨论：VA或NVA-FS的FS指数住院或选择后续FS结局的风险均无差异。这表明，对VA-FS患儿的随访护理不值得对NVA-FS进行关注。 （C）2014 Elsevier Ltd.保留所有权利。

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    《Vaccine》 |2014年第48期|共7页
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