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Raccoonpoxvirus safety in immunocompromised and pregnant mouse models

机译：浣熊痘病毒在免疫受损和怀孕小鼠模型中的安全性

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摘要

Numerous poxviruses infect humans and animal hosts, and a poxvirus vaccine with an improved safety profile is needed as the current vaccinia virus vaccine is contraindicated in individuals that have a history of eczema or heart disease, or are immunocompromised or pregnant. In addition, poxviruses make excellent vaccine vectors for other infectious diseases and cancer. Raccoonpoxvirus is a naturally occurring attenuated North American poxvirus, and thus it is of interest as a vaccine vector platform. This study explores the effects of raccoonpoxvirus in SCID and Nude immunocompromised and pregnant mouse models to assess its virulence and probable safety for human and animal populations. We also analyzed the safety of recombinant raccoonpox carrying a gene expressing a foreign antigen, rabies virus glycoprotein, designed for heterologous vaccine protection. Our data show that recombinant raccoonpoxviruses are avirulent in many cases and are much safer than vaccinia virus (strain WR). Raccoonpoxviruses also have the advantage of being able to replicate in mammalian cells. This allows increased immunogenicity and production efficiency, giving an advantage over non replicating vectors such as Modified Vaccinia Ankara MVA or canarypoxvirus
机译：大量痘病毒感染人类和动物宿主，并且需要一种具有改进安全性的痘病毒疫苗，因为目前的痘苗病毒疫苗被禁止用于有湿疹或心脏病史，免疫力低下或怀孕的人。此外，痘病毒是用于其他传染病和癌症的优秀疫苗载体。浣熊痘病毒是一种天然存在的减毒北美痘病毒，因此作为疫苗载体平台受到关注。这项研究探索了浣熊痘病毒在SCID和Nude免疫功能低下和怀孕的小鼠模型中的作用，以评估其毒力和对人畜的安全性。我们还分析了携带表达异源疫苗狂犬病病毒糖蛋白的基因的重组浣熊的安全性，该基因旨在保护异源疫苗。我们的数据表明，重组浣熊痘病毒在许多情况下是无毒的，并且比牛痘病毒（WR株）安全得多。浣熊痘病毒还具有能够在哺乳动物细胞中复制的优势。这样可以提高免疫原性和生产效率，相对于非复制型载体（如改良的痘苗安卡拉MVA或金丝雀痘病毒）具有优势

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