...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Vaccine >Comparison of two commercial vaccines against visceral leishmaniasis in dogs from endemic areas: IgG, and subclasses, parasitism, and parasite transmission by xenodiagnosis.
【24h】

Comparison of two commercial vaccines against visceral leishmaniasis in dogs from endemic areas: IgG, and subclasses, parasitism, and parasite transmission by xenodiagnosis.

机译：两种来自地方性地区的犬类针对内脏利什曼病的商业疫苗的比较：IgG，以及通过异种诊断的亚类，寄生虫和寄生虫传播。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: The incidence of zoonotic canine visceral leishmaniasis (CVL) would decrease if dogs were effectively vaccinated; however, additional data on the efficacy of canine vaccines are required for their approved preventative use. Purpose: To prospectively evaluate vaccination outcomes using two products commercially available in Brazil, with respect to adverse reactions (reactogenicity), humoral response, disease signs, parasitism, and parasite infectiousness in naturally exposed pet dogs in an endemic area of visceral leishmaniasis (VL). Methods: From 2010 to 2012, healthy dogs were vaccinated with LeishmuneReg. (50 animals) or Leish-TecReg. (50 animals). Each dog was examined to identify clinical signs during peri- and post-vaccination procedures every 2 months for 11 months to identify the presence of parasites or parasite DNA in splenic samples using culturing or PCR, respectively. Levels of anti-Leishmania IgG, IgG1, and IgG2 were quantified in sera by ELISA and infectiousness was assessed by xenodiagnosis. Results: Adverse effects occurred in 2.2% (1/45) and 13.0% (6/46) of the animals in the LeishmuneReg. and Leish-TecReg. groups, respectively. IgG levels peaked on the 21st day following the first dose of LeishmuneReg. and on the 21st day after the second dose of Leish-TecReg.. The final seropositivity rate for IgG was 32.5% (13/40) and 30.9% (13/42) in the LeishmuneReg. and Leish-TecReg. groups, respectively. The LeishmuneReg. group presented higher levels of IgG1 and IgG2 compared to the Leish-TecReg. group (p<0.001), and ELISA reactivity in both vaccinated groups was significantly lower (p<0.001) than in infected positive control dogs. Parasitism was observed in 12.2% (5/41) of the LeishmuneReg. group, and 7.9% (3/38) of the Leish-TecReg. group, with xenodiagnostic transmission rates of Leishmania to Lutzomyia longipalpis of 5.1% (2/39), and 5.4% (2/37), respectively. Conclusions: No significant differences were observed in dogs vaccinated with LeishmuneReg. or Leish-TecReg., with respect to LVC clinical aspects, parasitism, IgG seropositivity, or dog infectiousness. The LeishmuneReg.-vaccinated animals presented higher levels of IgG, IgG1, and IgG2. The animals vaccinated with Leish-TecReg. exhibited adverse reactions with greater frequency and severity.
机译：背景：如果对犬进行有效的疫苗接种，人畜共患的内脏利什曼病（CVL）的发生率将会降低。但是，要获得批准的预防用途，还需要有关犬疫苗功效的其他数据。目的：使用内脏利什曼病（VL）流行地区的自然暴露的宠物狗，使用在巴西出售的两种产品对不良反应（反应原性），体液反应，疾病迹象，寄生虫和寄生虫感染性进行前瞻性评估疫苗接种结果。方法：2010年至2012年，对健康犬进行LeishmuneReg疫苗接种。 （50只动物）或Leish-TecReg。 （50只动物）。每2个月在疫苗接种前后（每11个月）检查一次犬的临床体征，以分别通过培养或PCR鉴定脾脏样本中是否存在寄生虫或寄生虫DNA。通过ELISA定量血清中抗利什曼原虫IgG，IgG1和IgG2的水平，并通过异种诊断来评估传染性。结果：在利什蒙地区，有2.2％（1/45）和13.0％（6/46）的动物发生了不良反应。和Leish-TecReg。组。首次服用LeishmuneReg后的第21天，IgG水平达到峰值。在LeishmuneReg中，IgG的最终血清阳性率为32.5％（13/40）和30.9％（13/42）。和Leish-TecReg。组。利什蒙区。与Leish-TecReg相比，该组的IgG1和IgG2含量更高。组（p ＜0.001），并且两个接种组的ELISA反应性均显着低于感染的阳性对照犬（p ＜0.001）。在LeishmuneReg的12.2％（5/41）中观察到寄生虫。组和Leish-TecReg的7.9％（3/38）。组，利什曼原虫对长足卢氏菌的异种诊断传播率分别为5.1％（2/39）和5.4％（2/37）。结论：LeishmuneReg疫苗接种的狗没有观察到显着差异。或Leish-TecReg。，就LVC临床方面，寄生虫，IgG血清阳性或犬传染性而言。接种LeishmuneReg。的动物呈现较高水平的IgG，IgG1和IgG2。用Leish-TecReg疫苗接种的动物。出现不良反应的频率和严重性更高。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号