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首页> 外文期刊>Vaccine >Post-marketing surveillance of adverse events following immunization with inactivated quadrivalent and trivalent influenza vaccine in health care providers in Western Australia
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Post-marketing surveillance of adverse events following immunization with inactivated quadrivalent and trivalent influenza vaccine in health care providers in Western Australia

机译：西澳大利亚州医疗保健提供者中灭活的四价和三价流感疫苗免疫后不良事件的上市后监测

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In 2015, inactivated quadrivalent influenza vaccine (QIV) was first introduced into the Australian market. A routine vaccine safety surveillance system in Western Australia was used to conduct post-licensure surveillance of adverse events following immunization with inactivated QIV and trivalent influenza vaccines (TIV) in a sample of 1685 healthcare providers (HCPs). A similar percentage of HCPs who received QIV reported having any reaction seven days post-vaccination as HCPs who received TIV (13.6 vs. 12.8%, respectively; p = 0.66). However, a slightly higher percentage of HCPs who received QIV reported pain or swelling at the injection site as compared to HCPs who received TIV (6.9% vs. 4.2%, respectively; p = 0.02). No serious vaccine-associated adverse events were detected during follow-up of either vaccine. Acknowledging the study limitations, the results of this post-marketing surveillance support the safety of QIV, suggesting there is little difference in the reactogenicity of QIV as compared to TIV. Crown Copyright (C) 2015 Published by Elsevier Ltd. All rights reserved.
机译：2015年，灭活的四价流感疫苗（QIV）首次引入澳大利亚市场。西澳大利亚州的常规疫苗安全监视系统用于对1685名医疗服务提供者（HCP）进行灭活QIV和三价流感疫苗（TIV）免疫后对不良事件进行许可后监视。接受QIV的HCP接种后7天有任何反应，与接受TIV的HCP相似（分别为13.6和12.8％; p = 0.66）。但是，与接受TIV的HCP相比，接受QIV的HCP的注射部位出现疼痛或肿胀的比例略高（分别为6.9％和4.2％; p = 0.02）。两种疫苗的随访期间均未检测到严重的疫苗相关不良事件。认识到研究的局限性，这种上市后监测的结果支持了QIV的安全性，这表明与TIV相比，QIV的反应原性几乎没有差异。 Crown版权所有（C）2015，由Elsevier Ltd.发行。保留所有权利。

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