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Protection induced by early stage vaccination with pandemic influenza virus-like particles

机译：大流行性流感病毒样颗粒的早期疫苗接种诱导的保护

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The 2009 worldwide influenza pandemic emphasized the need for new approaches to develop emergency vaccines. In this study, a virus-like particle vaccine comprised of hemagglutinin (HA) and M1 from the pandemic influenza virus A/California/04/09 were used and its ability to induce protective immunity during the early stage of vaccination was assessed in a mouse model. A single intramuscular vaccination with virus-like particles (VLPs) provided protection on days 4 and 7 post-vaccination against lethal virus challenge with only moderate body weight loss. VLP vaccination induced significantly higher IgG antibody responses and high hemagglutinin inhibition (HAI) titers on day 4 post-vaccination. A predominant IgG2a antibody response and viral neutralizing antibodies were induced on day 7. These immune responses were closely correlated with protection. Lung virus titers decreased significantly on day 7 compared to those on day 4 post-vaccination. The lung virus titer on day 4 post-vaccination also decreased significantly compared to that of the naive control. These results demonstrate that VLP vaccination confers effective protection during the early stage after vaccination in a mouse model. (C) 2016 Elsevier Ltd. All rights reserved.
机译：2009年全球流感大流行强调了开发应急疫苗的新方法的必要性。在这项研究中，使用了由血凝素（HA）和大流行性流感病毒A / California / 04/09的M1组成的类病毒颗粒疫苗，并在小鼠中评估了其在疫苗接种早期诱导保护性免疫的能力。模型。病毒样颗粒（VLP）的单次肌内疫苗接种在疫苗接种后第4天和第7天提供了针对致命病毒攻击的保护作用，且体重仅中等减轻。接种疫苗后第4天，VLP疫苗接种可诱导明显更高的IgG抗体反应和较高的血凝素抑制（HAI）效价。在第7天诱导了主要的IgG2a抗体应答和病毒中和抗体。这些免疫应答与保护密切相关。与接种后第4天相比，第7天肺病毒滴度显着下降。接种后第4天的肺病毒滴度也比未接种过的对照组明显降低。这些结果表明，在小鼠模型中，接种疫苗后的早期阶段，VLP疫苗接种可提供有效的保护。 （C）2016 Elsevier Ltd.保留所有权利。

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