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The dengue vaccine pipeline: Implications for the future of dengue control

机译：登革热疫苗管道：对登革热控制未来的启示

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摘要

Dengue has become the most rapidly expanding mosquito-borne infectious disease on the planet, surpassing malaria and infecting at least 390 million people per year. There is no effective treatment for dengue illness other than supportive care, especially for severe cases. Symptoms can be mild or life-threatening as in dengue hemorrhagic fever and dengue shock syndrome. Vector control has been only partially successful in decreasing dengue transmission. The potential use of safe and effective tetravalent dengue vaccines is an attractive addition to prevent disease or minimize the possibility of epidemics. There are currently no licensed dengue vaccines. This review summarizes the current status of all dengue vaccine candidates in clinical evaluation. Currently five candidate vaccines are in human clinical trials. One has completed two Phase III trials, two are in Phase II trials, and three are in Phase I testing. (C) 2015 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
机译：登革热已成为地球上增长最快的蚊媒传染病，超过了疟疾，每年感染至少3.9亿人。除了支持治疗，没有针对登革热疾病的有效治疗方法，特别是对于严重病例。如登革出血热和登革热休克综合症，症状可能较轻或危及生命。媒介控制在减少登革热传播方面仅取得了部分成功。安全有效的四价登革热疫苗的潜在用途是预防疾病或使流行病的可能性最小的有吸引力的补充。当前没有获得许可的登革热疫苗。这篇综述总结了所有登革热疫苗候选者在临床评估中的现状。目前有五种候选疫苗正在人类临床试验中。一个已经完成了两个III期试验，两个已经在II期试验中，三个已经在I期试验中。 （C）2015作者。由Elsevier Ltd.发布。这是CC BY-NC-ND许可（http://creativecommons.org/licenses/by-nc-nd/4.0/）下的开放获取文章。

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