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Status of vaccine research and development for Campylobacter jejuni

机译：空肠弯曲菌疫苗的研究现状

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Campylobacter jejuni is one of the leading causes of bacterial diarrhea worldwide and is associated with a number of sequelae, including Guillain Barre Syndrome, reactive arthritis, irritable bowel syndrome and growth stunting/malnutrition. Vaccine development against C. jejuni is complicated by its antigenic diversity, a lack of small animal models, and a poor understanding of the bacterium's pathogenesis. Vaccine approaches have been limited to recombinant proteins, none of which have advanced beyond Phase I testing. Genomic analyses have revealed the presence of a polysaccharide capsule on C. jejuni. Given the success of capsule-conjugate vaccines for other mucosal pathogens of global importance, efforts to evaluate this established approach for C. jejuni are also being pursued. A prototypical capsule-conjugate vaccine has demonstrated efficacy against diarrheal disease in non-human primates and is currently in Phase I testing. In addition to proof of concept studies, more data on the global prevalence of capsular types, and a better understanding of the acute and chronic consequences of C. jejuni are needed to inform investments for a globally relevant vaccine. (C) 2016 World Health Organization; licensee Elsevier Ltd.
机译：空肠弯曲菌是全世界细菌性腹泻的主要原因之一，并与许多后遗症相关，包括格林兰氏巴利氏综合症，反应性关节炎，肠易激综合症和生长发育不良/营养不良。空肠弯曲杆菌的疫苗开发因其抗原多样性，缺乏小动物模型以及对细菌发病机理的了解而变得复杂。疫苗方法仅限于重组蛋白，这些蛋白都没有超过I期测试。基因组分析表明空肠弯曲杆菌上存在多糖胶囊。鉴于具有全球重要性的其他粘膜病原体的胶囊结合疫苗的成功应用，人们也在努力评估这种针对空肠弯曲菌的既定方法。一种典型的胶囊结合疫苗已证明可在非人类灵长类动物中抵抗腹泻疾病，目前正处于I期测试。除了概念验证研究之外，还需要更多有关全球荚膜类型流行率的数据以及对空肠弯曲杆菌急性和慢性后果的更好了解，才能为全球相关疫苗的投资提供信息。 （C）2016世界卫生组织;被许可人爱思唯尔有限公司

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