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Risk of underlying chronic medical conditions for invasive pneumococcal disease in adults

机译：成人侵袭性肺炎球菌疾病的潜在慢性医学状况风险

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Purpose: In the United States, the 13-valent pneumococcal conjugate vaccine is recommended in persons 65 years of age, and persons = 65 years of age with immunocompromising (IC) conditions. For invasive pneumococcal disease (IPD) prevention in those = 65 with non-IC medical conditions, the 23-valent polysaccharide vaccine is recommended. This group is at higher risk of IPD than the general population, but the level of risk is not well-quantified. We estimated IPD risk by individual underlying medical conditions, and by total number of conditions, for persons 18 years of age. We calculated the relative risks (RR) of various medical conditions, comparing the incident IPD cases to the general study population, and used Poisson regression models to estimate an IPD RR, adjusting for other conditions. We also examined IPD incidence by number of conditions diagnosed in each calendar year, using a risk-stacking model.
机译：目的：在美国，建议65岁以下人群和免疫缺陷（IC）病患≤65岁人群使用13价肺炎球菌结合疫苗。对于非IC疾病中≤65的侵入性肺炎球菌疾病（IPD）预防，建议使用23价多糖疫苗。与普通人群相比，该人群患IPD的风险更高，但其风险水平并未得到很好的量化。我们通过个人年龄和18岁以下患者的基本医疗状况以及疾病总数估算了IPD风险。我们计算了各种医疗状况的相对风险（RR），将IPD的突发事件与一般研究人群进行了比较，并使用Poisson回归模型估算了IPD RR，并针对其他状况进行了调整。我们还使用风险堆积模型，通过每个日历年中诊断出的疾病数量检查了IPD发生率。

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