A novel DNA vaccine for reduction of PRRSV-induced negative immunomodulatory effects: A proof of concept

Suradhat Sanipa; Wongyanin Piya; Kesdangsakonwut Sawang; Teankum Komkrich; Lumyai Mongkol; Triyarach Sittikorn; Thanawongnuwech Roongroje

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A novel DNA vaccine for reduction of PRRSV-induced negative immunomodulatory effects: A proof of concept

机译：减少PRRSV诱导的负免疫调节作用的新型DNA疫苗：概念验证

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Background: Viral-induced interleukin (IL)-10 and regulatory T lymphocytes (Tregs) are believed to play a major role in shaping the immunological and clinical outcomes following Porcine Reproductive and Respiratory Syndrome virus (PRRSV) infection. Recently, it has been shown that PRRSV nucleocapsid (N) protein can induce IL-10 production which is essential for induction of PRRSV-specific Tregs. We hypothesized that immunity to N protein should reduce PRRSV-induced negative immunomodulatory effects which will be essential for establishing proper anti-PRRSV immunity in infected pigs.

机译：背景：病毒诱导的白介素（IL）-10和调节性T淋巴细胞（Tregs）被认为在猪繁殖与呼吸综合征病毒（PRRSV）感染后，在影响免疫和临床结局方面起着重要作用。近来，已经显示PRRSV核衣壳（N）蛋白可以诱导IL-10产生，这对于诱导PRRSV特异性Treg是必不可少的。我们假设对N蛋白的免疫应减少PRRSV诱导的负免疫调节作用，这对于在感染猪中建立适当的抗PRRSV免疫至关重要。

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《Vaccine》 |2015年第32期|共7页
作者
Suradhat Sanipa; Wongyanin Piya; Kesdangsakonwut Sawang; Teankum Komkrich; Lumyai Mongkol; Triyarach Sittikorn; Thanawongnuwech Roongroje;
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正文语种 eng
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关键词
PRRSV; DNA vaccine; Nucleocapsid protein; Tregs;

机译：PRRSV;DNA疫苗;核衣壳蛋白;Tregs;

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1. A novel DNA vaccine for reduction of PRRSV-induced negative immunomodulatory effects: A proof of concept [J] . Suradhat Sanipa, Wongyanin Piya, Kesdangsakonwut Sawang, Vaccine . 2015,第32期

机译：减少PRRSV诱导的负免疫调节作用的新型DNA疫苗：概念验证
2. Solid vaccine protection against SIV in rhesus monkeys provides proof-of-concept for further evaluation of a novel HIV vaccine approach in humans [J] . EsparzaJ. Expert review of vaccines . 2012,第5期

机译：恒河猴针对SIV的固体疫苗保护为进一步评估人类新型HIV疫苗方法提供了概念验证
3. Near real-time surveillance for influenza vaccine safety: proof-of-concept in the Vaccine Safety Datalink Project. [J] . Greene SK, Kulldorff M, Lewis E American Journal of Epidemiology . 2010,第2期

机译：流感疫苗安全性的近实时监视：疫苗安全性数据链接项目中的概念验证。
4. RNA Particle FMDV vaccine proof of concept study in cattle [C] . Kurt I. Kamrud, John Neilan, Jose Barrera, Annual Meeting of the American Association of Swine Veterinarians . 2011

机译：RNA粒子FMDV疫苗证明牛的概念研究
5. Immunomodulatory effects of porcine interleukin-18 on a modified live vaccine immune response against swine influenza virus [D] . Kappes, Matthew Allan 2009

机译：猪白介素18对改良的活疫苗针对猪流感病毒的免疫应答的免疫调节作用
6. Reduction of relative centrifugal forces increases growth factor release within solid platelet-rich-fibrin (PRF)-based matrices: a proof of concept of LSCC (low speed centrifugation concept) [O] . K. El Bagdadi, A. Kubesch, X. Yu, -1

机译：相对离心力的减少会增加基于富血小板纤维蛋白（PRF）的固体基质中生长因子的释放：LSCC概念的证明（低速离心概念）
7. A novel DNA vaccine for reduction of PRRSV-induced negative immunomodulatory effects: A proof of concept [O] . Sanipa Suradhat, Piya Wongyanin, Sawang Kesdangsakonwut, 2015

机译：一种新型DNA疫苗，用于降低PRRSV诱导的阴性免疫调节效果：概念证明

A novel DNA vaccine for reduction of PRRSV-induced negative immunomodulatory effects: A proof of concept

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