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首页> 外文期刊>Vaccine >Brucella abortus S19 and RB51 vaccine immunogenicity test: Evaluation of three mice (BALB/c, Swiss and CD-1 (R)) and two challenge strains (544 and 2308)
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Brucella abortus S19 and RB51 vaccine immunogenicity test: Evaluation of three mice (BALB/c, Swiss and CD-1 (R)) and two challenge strains (544 and 2308)

机译：流产布鲁氏菌S19和RB51疫苗免疫原性测试：评估三只小鼠（BALB / c，Swiss和CD-1（R））和两种攻击菌株（544和2308）

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The aim of the present study was to evaluate the use of different mouse strains (BALB/c, Swiss and CD-1 (R)) and different challenge strains (Brucella abortus 544 and 2308) in the study of B. abortus vaccine (S19 and RB51) immunogenicity test in the murine model. No significant difference in B. abortus vaccine potency assay was found with the use of B. abortus 544 or B. abortus 2308 as challenge strain. Results of variance analysis showed an interaction between treatment and mouse strain; therefore these parameters could not be compared separately. When CD-1 (R) groups were compared, those vaccinated showed significantly lower counts than non-vaccinated ones (P0.05), independently of the vaccine received (S19 or RB51). Similar results were observed on BALB/c groups. However, in Swiss mouse groups, S19 was more protective than RB51 (P0.05), which showed protection when compared to the non-vaccinated group (P0.05). In summary, data from the present study showed that CD-1 (R), BALB/c and Swiss mice strains, as well as both challenge strains, B. abortus strains 544 and 2308, can be used in immunogenicity tests of S19 and RB51 vaccines. (C) 2014 Elsevier Ltd. All rights reserved.
机译：本研究的目的是评估在流产芽孢杆菌疫苗（S19）研究中使用不同的小鼠品系（BALB / c，Swiss和CD-1（R））和不同的攻击品系（流产布鲁氏菌544和2308）。和RB51）小鼠模型的免疫原性测试。使用流产双歧杆菌544或流产双歧杆菌2308作为攻击菌株，在流产双歧杆菌疫苗效力测定中没有发现显着差异。方差分析结果显示治疗与小鼠品系之间存在相互作用。因此无法单独比较这些参数。比较CD-1（R）组时，接种疫苗的人的计数明显低于未接种疫苗的人（P <0.05），而与所接种的疫苗无关（S19或RB51）。在BALB / c组上观察到相似的结果。但是，在瑞士小鼠组中，S19比RB51更具保护性（P <0.05），与未接种疫苗的组相比，它具有保护作用（P <0.05）。总而言之，来自本研究的数据表明，CD-1（R），BALB / c和Swiss小鼠品系以及两种挑战品系流产的流产芽孢杆菌544和2308都可以用于S19和RB51的免疫原性测试疫苗。 （C）2014 Elsevier Ltd.保留所有权利。

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