A single-dose antihelminthic treatment does not influence immunogenicity of a meningococcal and a cholera vaccine in Gabonese school children

Brueckner Sina; Agnandji Selidji Todagbe; Elias Johannes; Berberich Stefan; Bache Emmanuel; Fernandes Jose; Loembe Marguerite Massinga; Hass Johanna; Lell Bertrand; Mordmueller Benjamin; Adegnika Ayola Akim; Kremsner Peter; Esen Meral

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A single-dose antihelminthic treatment does not influence immunogenicity of a meningococcal and a cholera vaccine in Gabonese school children

机译：单剂量抗蠕虫药治疗不会影响加蓬学龄儿童脑膜炎球菌和霍乱疫苗的免疫原性

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Background: We recently described the effect of a single-dose antihelminthic treatment on vaccine immunogenicity to a seasonal influenza vaccine. Here we report the effect of antihelminthics on the immunogenicity of a meningococcal vaccine and a cholera vaccine in primary school children living in Lambarene, Gabon. Since infection with helminths remains a major public health problem and the influence on cognitive and physical development as well as the immunomodulatory effects are well established, we investigated if a single-dose antihelminthic treatment prior to immunization positively influences antibody titers and vaccine-specific memory B-cells.

机译：背景：我们最近描述了单剂量抗蠕虫药治疗对季节性流感疫苗的疫苗免疫原性的影响。在这里，我们报告了抗蠕虫药对住在加蓬Lambarene的小学生脑膜炎球菌疫苗和霍乱疫苗的免疫原性的影响。由于寄生虫感染仍然是主要的公共卫生问题，并且对认知和身体发育以及免疫调节作用的影响已得到很好的确立，因此我们调查了免疫前单剂量抗寄生虫治疗是否会对抗体滴度和疫苗特异性记忆B产生积极影响-细胞。

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来源
《Vaccine》 |2016年第44期|共7页
作者
Brueckner Sina; Agnandji Selidji Todagbe; Elias Johannes; Berberich Stefan; Bache Emmanuel; Fernandes Jose; Loembe Marguerite Massinga; Hass Johanna; Lell Bertrand; Mordmueller Benjamin; Adegnika Ayola Akim; Kremsner Peter; Esen Meral;
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Helminth-infection; Albendazole; Cholera vaccine; Meningococcal vaccine; Immune response; Memory B-cells;

机译：蠕虫感染;阿苯达唑;霍乱疫苗;脑膜炎球菌疫苗;免疫应答;记忆B细胞;

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1. A single-dose antihelminthic treatment does not influence immunogenicity of a meningococcal and a cholera vaccine in Gabonese school children [J] . Brueckner Sina, Agnandji Selidji Todagbe, Elias Johannes, Vaccine . 2016,第44期

机译：单剂量抗蠕虫药治疗不会影响加蓬学龄儿童脑膜炎球菌和霍乱疫苗的免疫原性
2. Effect of Antihelminthic Treatment on Vaccine Immunogenicity to a Seasonal Influenza Vaccine in Primary School Children in Gabon: A Randomized Placebo-Controlled Trial [J] . Sina Brückner, Selidji T. Agnandji, Stefan Berberich, PLOS Neglected Tropical Diseases . 2015,第6期

机译：抗蠕虫药治疗对加蓬小学儿童季节性流感疫苗免疫原性的影响：一项随机安慰剂对照试验。
3. Effect of Antihelminthic Treatment on Vaccine Immunogenicity to a Seasonal Influenza Vaccine in Primary School Children in Gabon: A Randomized Placebo-Controlled Trial [J] . Sina Brückner, Selidji T. Agnandji, Stefan Berberich, PLOS Neglected Tropical Diseases . 2015,第6期

机译：抗蠕虫药治疗对加蓬小学儿童季节性流感疫苗免疫原性的影响：一项随机安慰剂对照试验。
4. Immunogenicity of live hog cholera vaccine produced by GPE- strain of hog cholera virus [C] . N. Takikawa, S. Ide, K. Saijo, Congress of the International Pig Veterinary Society . 1999

机译：GPE-猪霍乱病毒产生的活猪霍乱疫苗的免疫原性
5. Immunogenicity of quadrivalent meningococcal polysaccharide vaccine in children during a mass immunization campaign [D] . King, W. James 1995

机译：儿童大规模免疫接种过程中四价脑膜炎球菌多糖疫苗的免疫原性
6. Correction: Effect of Antihelminthic Treatment on Vaccine Immunogenicity to a Seasonal Influenza Vaccine in Primary School Children in Gabon: A Randomized Placebo-Controlled Trial [O] . 2015

机译：校正：加蓬小学生抗蠕虫药治疗对季节性流感疫苗的疫苗免疫原性的影响：随机安慰剂对照试验。
7. Effect of Antihelminthic Treatment on Vaccine Immunogenicity to a Seasonal Influenza Vaccine in Primary School Children in Gabon: A Randomized Placebo-Controlled Trial. [O] . Sina Brückner, Selidji T Agnandji, Stefan Berberich, 2015

机译：抗蠕虫治疗对加蓬小学儿童季节性流感疫苗疫苗免疫原性的影响：一项随机安慰剂对照试验。

A single-dose antihelminthic treatment does not influence immunogenicity of a meningococcal and a cholera vaccine in Gabonese school children

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