Highly stereoselective, cobalt(iii)-directed Mannich additions in water yielding α-methylamino acid products

Oerum S.; Krabbe P.; Schau-Magnussen M.; Furbo S.; Bendix J.; Hammersh?i A.

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Highly stereoselective, cobalt(iii)-directed Mannich additions in water yielding α-methylamino acid products

机译：水中高度立体选择性，钴（iii）定向的曼尼希添加剂，生成α-甲基氨基酸产物

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Highly stereoselective and rapid (<1 min) addition reactions to the imine double bond of 2-(methylimino)acetate complexes [L_4Co(O _2CCHNCH_3)]~(2+) [L_4 = (en)_2 (7), (tren) (11)] were achieved in aqueous solution with nitromethane, ethyl 3-oxobutanoate or diethyl malonate. The molecular structures of two product complexes, rac-(Δ*-R_C*-S_N*)- [Co(en)_2(O_2CCH[CH_2NO_2]NHCH _3)]ZnCl_4 and rac-(Δ*-R_C*- S_N*)-[Co(en)_2(O_2CCH[CH _2COCH_3]NHCH_3)]ZnCl_4, were established by X-ray diffraction.

机译：2-（甲基亚氨基）乙酸盐络合物[L_4Co（O _2CCHNCH_3）]〜（2+）[L_4 =（en）_2（7），（tren）的亚胺双键的高度立体选择性和快速（<1分钟）加成反应（11）在水溶液中用硝基甲烷，3-氧代丁酸乙酯或丙二酸二乙酯获得。两种产物配合物rac-（Δ* -R_C * -S_N *）-[Co（en）_2（O_2CCH [CH_2NO_2] NHCH _3）] ZnCl_4和rac-（Δ* -R_C *-S_N *）的分子结构通过X射线衍射建立了-[Co（en）_2（O_2CCH [CH _2COCH_3] NHCH_3）] ZnCl_4。

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《Dalton transactions: An international journal of inorganic chemistry》 |2013年第1期|共7页
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Oerum S.; Krabbe P.; Schau-Magnussen M.; Furbo S.; Bendix J.; Hammersh?i A.;
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1. Highly stereoselective, cobalt(iii)-directed Mannich additions in water yielding α-methylamino acid products [J] . Oerum S., Krabbe P., Schau-Magnussen M., Dalton transactions: An international journal of inorganic chemistry . 2013,第1期

机译：水中高度立体选择性，钴（iii）定向的曼尼希添加剂，生成α-甲基氨基酸产物
2. Highly Stereoselective Cobalt(III)-Catalyzed Three-Component C-H Bond Addition Cascade [J] . Boerth Jeffrey A., Hummel Joshua R., Ellman Jonathan A. Angewandte Chemie . 2016,第41期

机译：高度立体化钴（III） - 催化三组分C-H键加入级联
3. Titanium-Mediated Direct Carbon-Carbon Double Bond Formation to α-Trifluoromethyl Acids: A New Contribution to the Knoevenagel Reaction and a High-Yielding and Stereoselective Synthesis of α-Trifluoromethylacrylic Acids [J] . Yanmei Liu, Hua Lai, Bo Rong Advanced synthesis & catalysis . 2011,第17期

机译：钛介导的直接碳-碳双键形成α-三氟甲基酸：对Knoevenagel反应和α-三氟甲基丙烯酸的高产率和立体选择性合成的新贡献
4. Highly Stereoselective Synthesis with Polyborylated Reagents: Cross-coupling of 1,1.Diboryl-l-alkenes and Triple Aldehyde Addition of(Z)-l,2,3,4-Tetraboryl-2-butene [C] . Masaki Shimizu, Katsuhiro Shimono, Chihiro Nakamaki, Symposium on Organometallic Chemistry . 2004

机译：高度立体化合成具有聚合物化试剂：1,1.Diboryl-L-烯烃的交叉偶联和三重醛加入（Z）-L，2,3,4-四甲基-2-丁烯
5. Stereoselective Synthesis of alpha,alpha-Disubstituted Amino Acids Utilizing Porcine Liver Esterase and the Petasis Borono-Mannich Reaction. [D] . Guerrera, Cessandra. 2017

机译：利用猪肝酯酶和Petasis Borono-Mannich反应立体选择性地合成α，α-二取代氨基酸。
6. Synthesis of Tetrahydropyridazines by a Metal-carbene Directed Highly Enantioselective Vinylogous N-H Insertion/Lewis Acid Catalyzed Diastereoselective Mannich Addition [O] . Dr. Xinfang Xu, Dr. Peter Y. Zavalij, Prof. Michael P. Doyle -1

机译：用金属 - 甲基甲基指导高度映选择性乙烯基N-H插入/路易斯酸催化的二氢吡啶的合成
7. Highly Stereoselective Cobalt(III)-Catalyzed Three-Component C−H Bond Addition Cascade [O] . Jeffrey A. Boerth, Joshua R. Hummel, Jonathan A. Ellman 2016

机译：高度立体化钴（III） - 催化三组分C-H键加入级联

Highly stereoselective, cobalt(iii)-directed Mannich additions in water yielding α-methylamino acid products

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