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首页> 外文期刊>Dalton transactions: An international journal of inorganic chemistry >The syntheses and characterizations of vanadium complexes with 1,2-dihydroxyanthraquinone and the structure-effect relationship in their in vitro anticancer activities
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The syntheses and characterizations of vanadium complexes with 1,2-dihydroxyanthraquinone and the structure-effect relationship in their in vitro anticancer activities

机译：钒与1,2-二羟基蒽醌配合物的合成，表征及其体外抗癌活性的结构效应关系

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[V~VO_2(O_2C_(14)H_6O _2)(C_5N_2H_(12))](C_5N _2H_(13))(CH_3OH) (1) and {Na[V~VO(O _2C_(14)H_6O_2)_2][(CH _3)_2NCHO]}_n (2) have been synthesized by the reaction of V_2O_5 and NaVO_3 with aromatic 1,2-diol (1,2-dihydroxyanthraquinone), and their molecular and crystal structures have been determined by X-ray diffraction. MTT assay tests of the V~VO_2L_AL_B and V~VOL _2 complexes against cancer cells have revealed that, when L is catechol, VOL_2 showed broad-spectrum, high anticancer activities which were proportional to their concentration; however when L is naphthol or alizarin, VOL_2 displayed little effect towards the cancer cells; moreover, complex 1 in the coordination model of V~VO _2L_AL_B showed specifically higher inhibition (88.65%) against HCT-8 than the clinical anticancer drug Fu-5 (69.97%). The results revealed that both the V(v) and the ligands cannot influence the inhibition against cancer cells individually. The mechanism of the broad-spectrum anticancer activities of VOL_2 when L is catechol ligand might originate from the redox activities of V~V/V~(IV) which regulate the concentration of ROS (reactive oxygen species). N-Methylpiperazine formed as a by-product in complex 1 was confirmed by ~1H NMR and its formation mechanism catalyzed by V_2O _5 has been deduced.
机译：[V〜VO_2（O_2C_（14）H_6O _2）（C_5N_2H_（12））] [C_5N _2H_（13））（CH_3OH）（1）和{Na [V〜VO（O _2C_（14）H_6O_2）_2] [ （CH _3）_2NCHO]} _ n（2）是通过V_2O_5和NaVO_3与芳香族1,2-二醇（1,2-二羟基蒽醌）的反应合成的，其分子和晶体结构已通过X射线衍射确定。对癌细胞的V〜VO_2L_AL_B和V〜VOL_2复合物的MTT分析测试表明，当L为儿茶酚时，VOL_2表现出广谱，高抗癌活性，与它们的浓度成正比。然而，当L为萘酚或茜素时，VOL_2对癌细胞的作用很小;此外，V〜VO _2L_AL_B协调模型中的复合物1对HCT-8的抑制作用（88.65％）比临床抗癌药物Fu-5的抑制作用（69.97％）特别高。结果表明，V（v）和配体都不能单独影响对癌细胞的抑制作用。当L为邻苯二酚配体时，VOL_2的广谱抗癌机制可能源于V〜V / V〜（IV）的氧化还原活性，其调节ROS的浓度。通过〜1H NMR证实了配合物1中作为副产物形成的N-甲基哌嗪，并推导了其被V_2O _5催化的形成机理。

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