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Periodic transcription: A cycle within a cycle [Review]

机译:周期性转录:一个循环中的一个循环[评论]

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摘要

Studies in model organisms indicate that one in every five genes may be subject to cell cycle regulated transcription. Moreover, a high proportion of periodically expressed genes have discrete roles in the cell division process, and their peaks of expression coincide with the interval during which they function. This periodic transcription is commonly regulated by transcription factors that are also periodically transcribed, and there is a growing number of examples where the transcription factors and their targets are conserved in yeast and mammalian cells. As such, it is worth considering why these regulatory circuits persist in such great number, how they are achieved and what role they may play in the cell cycle.
机译:对模型生物的研究表明,每五个基因中就有一个可能受到细胞周期调控的转录。此外,高比例的周期性表达的基因在细胞分裂过程中具有离散的作用,并且它们的表达峰与它们起作用的间隔一致。该周期性转录通常由也周期性转录的转录因子调节,并且在越来越多的例子中,转录因子及其靶标在酵母和哺乳动物细胞中是保守的。因此,值得考虑的是,为什么这些调节电路如此大量地存在,如何实现以及它们在细胞周期中可能起什么作用。

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