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首页> 外文期刊>Dalton transactions: An international journal of inorganic chemistry >Mesoporous silica nanoparticles for enhancing the delivery efficiency of immunostimulatory DNA drugs?
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Mesoporous silica nanoparticles for enhancing the delivery efficiency of immunostimulatory DNA drugs?

机译：中孔二氧化硅纳米颗粒可提高免疫刺激DNA药物的递送效率？

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摘要

We developed a potential immunostimulatory double-stranded DNA (dsDNA) delivery system by the binding of dsDNA to amino-modified mesoporous silica nanoparticles (MSNs) to form MSN-NH_2/dsDNA complexes. Serum stability, in vitro cytotoxicity, cell uptake, and type I interferon-α (IFN-α) induction of MSN-NH_2/dsDNA complexes were evaluated. The results showed that MSN-NH_2 nanoparticles had no cytotoxicity to Raw 264.7 cells, and MSN-NH_2/dsDNA complexes enhanced the serum stability of dsDNA due to the protection by nanoparticles and exhibited a high efficiency of cell uptake due to a small particle size and excellent dispersity. Most importantly, MSN-NH_2/dsDNA complexes significantly enhanced the level of IFN-α induction, triggered by cytosolic DNA sensor proteins. Therefore, binding of immunostimulatory DNA to MSNs would play a promising role for enhancing the delivery efficiency of immunostimulatory DNA drugs.
机译：我们通过将dsDNA与氨基修饰的介孔二氧化硅纳米粒子（MSNs）结合形成MSN-NH_2 / dsDNA复合物，开发了一种潜在的免疫刺激性双链DNA（dsDNA）递送系统。评估了血清稳定性，体外细胞毒性，细胞摄取和MSN-NH_2 / dsDNA复合物的I型干扰素-α（IFN-α）诱导。结果表明，MSN-NH_2纳米颗粒对Raw 264.7细胞没有细胞毒性，并且MSN-NH_2 / dsDNA复合物由于受到纳米颗粒的保护而增强了dsDNA的血清稳定性，并且由于粒径小而具有较高的细胞摄取效率。优异的分散性。最重要的是，MSN-NH_2 / dsDNA复合物显着增强了由胞质DNA传感器蛋白触发的IFN-α诱导水平。因此，免疫刺激DNA与MSN的结合将在提高免疫刺激DNA药物的递送效率方面发挥有希望的作用。

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