Dinuclear zinc(II) complexes containing (benzimidazol-2-yl)benzene that overcome drug resistance in hepatocellular carcinoma cells through induction of mitochondria fragmentation

Qiang Xie; Shenggui Liu; Xiaoling Li; Qiong Wu; Zuandi Luo; Xiaoyan Fu; Wenqiang Cao; Guoqiang Lan; Dan Li; Wenjie Zheng; Tianfeng Chen

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Dinuclear zinc(II) complexes containing (benzimidazol-2-yl)benzene that overcome drug resistance in hepatocellular carcinoma cells through induction of mitochondria fragmentation

机译：含（苯并咪唑-2-基）苯的双核锌（II）配合物可通过诱导线粒体片段化来克服肝癌细胞的耐药性

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Herein we demonstrated that dinuclear zinc complexes could overcome drug resistance in R-HepG2 drug resistance hepatocellular carcinoma cells through induction of mitochondria-mediated apoptosis or by triggering mitochondria fragmentation, depletion of the membrane potential and intracellular ATP levels.

机译：在本文中，我们证明了双核锌复合物可通过诱导线粒体介导的凋亡或触发线粒体片段化，膜电位消耗和细胞内ATP水平克服R-HepG2耐药性肝癌细胞中的耐药性。

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《Dalton transactions: An international journal of inorganic chemistry》 |2014年第19期|共4页
作者
Qiang Xie; Shenggui Liu; Xiaoling Li; Qiong Wu; Zuandi Luo; Xiaoyan Fu; Wenqiang Cao; Guoqiang Lan; Dan Li; Wenjie Zheng; Tianfeng Chen;
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正文语种 eng
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Dinuclear zinc(II); complexes containing; (benzimidazol-2-yl)benzene;

机译：双核锌（II）;含（苯并咪唑-2-基）苯的配合物;

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1. Dinuclear zinc(II) complexes containing (benzimidazol-2-yl)benzene that overcome drug resistance in hepatocellular carcinoma cells through induction of mitochondria fragmentation [J] . Qiang Xie, Shenggui Liu, Xiaoling Li, Dalton transactions: An international journal of inorganic chemistry . 2014,第19期

机译：含（苯并咪唑-2-基）苯的双核锌（II）配合物可通过诱导线粒体片段化来克服肝癌细胞的耐药性
2. Dinuclear zinc(II) complexes containing (benzimidazol-2-yl)benzene that overcome drug resistance in hepatocellular carcinoma cells through induction of mitochondria fragmentation [J] . Qiang Xie, Shenggui Liu, Xiaoling Li, Dalton transactions: An international journal of inorganic chemistry . 2014,第19期

机译：含（苯并咪唑-2-基）苯的双核锌（II）配合物可通过诱导线粒体片段化来克服肝癌细胞的耐药性
3. PEG-nanolized ultrasmall selenium nanoparticles overcome drug resistance in hepatocellular carcinoma HepG2 cells through induction of mitochondria dysfunction [J] . Shanyuan Zheng, Xiaoling Li, Yibo Zhang, International Journal of Nanomedicine . 2012,第8期

机译：PEG修饰的超小硒纳米颗粒通过诱导线粒体功能障碍克服了肝细胞癌HepG2细胞的耐药性
4. Lipid Peroxidation and Cyclooxygenase-2 Activity in Human Hepatocellular Carcinoma Cell Lines With and Without Multiple Drug Resistance: Correlation With Cell Growth [C] . Emanuela Masini, Ornella Fantappie, Iacopo Sardi, International Stereotactic Radiosurgery Society . 2000

机译：脂质过氧化与人肝细胞癌细胞系中的脂质过氧化和环氧化酶-2活性，无多种耐药性：与细胞生长的相关性
5. Mechanistic Study of the Effect of CDH1 Promoter Hypermethylation on Drug Resistance and Related Gene Expression in Multidrug Resistant Human Hepatocellular Carcinoma R-HepG2 Cells. [D] . Jiang, Lei. 2010

机译：CDH1启动子甲基化对多药耐药人肝细胞癌R-HepG2细胞耐药性及相关基因表达影响的机理研究。
6. PEG-nanolized ultrasmall selenium nanoparticles overcome drug resistance in hepatocellular carcinoma HepG2 cells through induction of mitochondria dysfunction [O] . Shanyuan Zheng, Xiaoling Li, Yibo Zhang, 2012

机译：PEG修饰的超小硒纳米颗粒通过诱导线粒体功能障碍克服了肝细胞癌HepG2细胞的耐药性
7. PEG-nanolized ultrasmall selenium nanoparticles overcome drug resistance in hepatocellular carcinoma HepG2 cells through induction of mitochondria dysfunction [O] . Tianfeng Chen 2012

机译：PEG纳米型超大硒纳米粒子通过诱导线粒体功能障碍克服肝细胞癌HepG2细胞中的耐药性

Dinuclear zinc(II) complexes containing (benzimidazol-2-yl)benzene that overcome drug resistance in hepatocellular carcinoma cells through induction of mitochondria fragmentation

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