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首页> 外文期刊>Dalton transactions: An international journal of inorganic chemistry >Multifunctional mesoporous hollow silica nanocapsules for targeted co-delivery of cisplatin-pemetrexed and MR imaging
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Multifunctional mesoporous hollow silica nanocapsules for targeted co-delivery of cisplatin-pemetrexed and MR imaging

机译：多功能介孔中空二氧化硅纳米胶囊用于顺铂-培美曲塞和MR成像的靶向共递送

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摘要

The development of theranostic mesoporous hollow silica nanospheres having therapeutic and diagnostic functions has been achieved. The exterior surface of the hollow mesoporous silica nanosphere was selectively acid functionalized and utilised to conjugate the anticancer drug cisplatin, the marker molecule folic acid (FA), and rhodamine isothiocyanate (RITC), whereas the interior space was utilised to encapsulate superparamagnetic CoFe_2O_4 nanoparticles as well as the hydrophobic anticancer drug pemetrexed. The hydrodynamic size of the synthesized multidrug loaded hollow particles is 130 nm in physiological pH and it is consistent over a long period. To the best of our knowledge this is the first report on fluorescent magnetic hollow spheres loaded with multiple therapeutic cargoes as well as a magnetic resonance imaging (MRI) contrast agent. The as prepared hollow spheres are biocompatible. The internalization efficiency of the drug loaded particle has been evaluated on folate receptor overexpressed (FR+ve) HeLa, FR?ve HaCat and 3T_3 cells. These drug loaded nanospheres exhibit enhanced cytotoxicity as compared to individual drugs. Such a strategy in the simultaneous administration of pemetrexed and platin drugs may open up opportunities for the treatment of lung cancer at its early stage.
机译：已经开发出具有治疗和诊断功能的治疗型介孔中空二氧化硅纳米球。中空介孔二氧化硅纳米球的外表面被选择性地酸官能化，并用于缀合抗癌药顺铂，标记分子叶酸（FA）和若丹明异硫氰酸酯（RITC），而内部空间则被用来封装超顺磁性CoFe_2O_4纳米粒子以及培美曲塞的疏水性抗癌药。合成的载有多药的空心颗粒的流体动力学尺寸在生理pH下为130 nm，并且在长期内保持一致。据我们所知，这是第一个关于装载有多种治疗药物以及磁共振成像（MRI）造影剂的荧光磁性空心球的报道。所制备的空心球是生物相容的。已经在叶酸受体过表达的（FR + ve）HeLa，FR？ve HaCat和3T_3细胞上评估了载药颗粒的内化效率。与单个药物相比，这些载有药物的纳米球表现出增强的细胞毒性。培美曲塞和铂金药物同时给药的这种策略可能为肺癌的早期治疗打开机会。

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