NAMI-A is highly cytotoxic toward leukaemia cell lines: evidence of inhibition of KCa 3.1 channels

Serena Pillozzi; Luca Gasparoli; Matteo Stefanini; Mirco Ristori; Massimo DAmico; Enzo Alessio; Federica Scaletti; Andrea Becchetti; Annarosa Arcangeli; Luigi Messori

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NAMI-A is highly cytotoxic toward leukaemia cell lines: evidence of inhibition of KCa 3.1 channels

机译：NAMI-A对白血病细胞系具有高度细胞毒性：抑制KCa 3.1通道的证据

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We report here that the established anticancer ruthenium(III) complex NAMI-A induces potent and selective cytotoxic effects in a few leukaemia cell lines. These results sound very surprising after 20 years of intense studies on NAMI-A, commonly considered as a "non-cytotoxic" antimetastatic agent. In addition, evidence is given for selective inhibition of KCa 3.1 channels. The implications of these findings are discussed.

机译：我们在这里报告已建立的抗癌钌（III）复合物NAMI-A在一些白血病细胞系中诱导有效和选择性的细胞毒性作用。在对NAMI-A进行了20年的深入研究之后，这些结果听起来非常令人惊讶。NAMI-A通常被认为是“非细胞毒性”抗转移剂。另外，给出了选择性抑制KCa 3.1通道的证据。讨论了这些发现的含义。

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来源
《Dalton transactions: An international journal of inorganic chemistry》 |2014年第32期|共6页
作者
Serena Pillozzi; Luca Gasparoli; Matteo Stefanini; Mirco Ristori; Massimo DAmico; Enzo Alessio; Federica Scaletti; Andrea Becchetti; Annarosa Arcangeli; Luigi Messori;
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正文语种 eng
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cytotoxic; inhibition; KCa 3.1 channels;

机译：细胞毒性;抑制;KCa 3.1通道;

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1. NAMI-A is highly cytotoxic toward leukaemia cell lines: evidence of inhibition of KCa 3.1 channels [J] . Serena Pillozzi, Luca Gasparoli, Matteo Stefanini, Dalton transactions: An international journal of inorganic chemistry . 2014,第32期

机译：NAMI-A对白血病细胞系具有高度细胞毒性：抑制KCa 3.1通道的证据
2. Immunosuppression by N-Methyl-d-Aspartate Receptor Antagonists Is Mediated through Inhibition of Kv1.3 and KCa3.1 Channels in T Cells [J] . Sascha Kahlfu?, Narasimhulu Simma, Judith Mankiewicz, Molecular and Cellular Biology . 2014,第5期

机译：N-甲基-d-天冬氨酸受体拮抗剂的免疫抑制作用是通过抑制T细胞中的Kv1.3和KCa3.1通道介导的。
3. Selective Inhibition of KCa3.1 Channels Mediates Adenosine Regulation of the Motility of Human T Cells [J] . Ameet A. Chimote, Peter Hajdu, Vladimir Kucher, The journal of immunology . 2013,第12期

机译：KCa3.1通道的选择性抑制介导腺苷调节人类T细胞的运动。
4. The Cytotoxicity of Mekai (Albertisia papuana Becc.) Root Extract on Breast Cancer Cell Lines T47D and Vero Cell Lines [C] . Elizabeth Betty Elok Kristiani, Laurentius Hartanto Nugroho, Soekarti Moeljopawiro, International Conference on Biological Science . 2016

机译：Mekai（Albertisia Papauana BECC）的细胞毒性。乳腺癌细胞系T47D和VERO细胞系上的根提取物
5. Structural Studies of the KCa3.1-CaM Channel Complex, a Critical Component of T-Cell Function [D] . Mortazavi, Shirin Rose. 2021

机译：KCA3.1-CAM通道复合物的结构研究，T细胞功能的关键组分
6. The Inhibition of KCa3.1 Channels Activity Reduces Cell Motility in Glioblastoma Derived Cancer Stem Cells [O] . Paola Ruggieri, Giorgio Mangino, Bernard Fioretti, -1

机译：KCa3.1通道活性的抑制降低细胞运动在胶质母细胞瘤来源的癌症干细胞
7. The Inhibition of KCa3.1 Channels Activity Reduces Cell Motility in Glioblastoma Derived Cancer Stem Cells [O] . Paola Ruggieri, Giorgio Mangino, Fioretti Bernard, 2012

机译：抑制KCa3.1通道活性降低胶质母细胞瘤衍生的癌症干细胞的细胞运动性。

NAMI-A is highly cytotoxic toward leukaemia cell lines: evidence of inhibition of KCa 3.1 channels

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