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首页> 外文期刊>Dalton transactions: An international journal of inorganic chemistry >Ultra-small mesoporous silica nanoparticles as efficient carriers for pH responsive releases of anti-cancer drugs
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Ultra-small mesoporous silica nanoparticles as efficient carriers for pH responsive releases of anti-cancer drugs

机译：超小介孔二氧化硅纳米颗粒可作为有效载体，用于抗癌药物的pH响应释放

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摘要

Mesoporous silica has emerged as one of the most promising carriers for drug delivery systems. However, the synthesis of ultra-small mesoporous silica nanoparticles (UMSNs) and their application in drug delivery remains a significant challenge. Here, spherical UMSNs (similar to 25 nm) have been synthesized and tested as drug carriers. Anti-cancer drugs mitoxantrone (MX), doxorubicin (DOX) and methotrexate (MTX) have been utilized as model drugs. The pH-responsive drug delivery system can be constructed based on electrostatic interactions between carriers and drug molecules. The UMSNs could store drugs under physiological conditions and release them under acidic conditions. Different pH-responsive release profiles were obtained in phosphate buffer solutions (PBSs) at the designed pH values (from 4.0 to 7.4). MX and DOX can be used in the pH-responsive delivery system, while MTX cannot be used. Furthermore, we found that the physiological stabilities of these drug molecules in UMSNs are in a decreasing order MX > DOX > MTX, which follows the order of their isoelectric point (pI) values.
机译：介孔二氧化硅已经成为药物递送系统中最有希望的载体之一。然而，超小介孔二氧化硅纳米粒子（UMSNs）的合成及其在药物递送中的应用仍然是一个重大挑战。在这里，球形UMSN（类似于25 nm）已经被合成并作为药物载体进行了测试。抗癌药米托蒽醌（MX），阿霉素（DOX）和甲氨蝶呤（MTX）已被用作模型药物。可以基于载体和药物分子之间的静电相互作用来构建pH响应药物传递系统。 UMSN可以在生理条件下储存药物，并在酸性条件下释放药物。在磷酸盐缓冲溶液（PBS）中在设计的pH值（4.0至7.4）下获得了不同的pH响应释放曲线。 MX和DOX可用于pH响应型输送系统，而不能使用MTX。此外，我们发现这些药物分子在UMSN中的生理稳定性按MX> DOX> MTX的降序排列，其顺序依次为它们的等电点（pI）值。

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