trans-Platinum(II) complex of 3-aminoflavone - synthesis, X-ray crystal structure and biological activities in vitro

Fabijanska Malgorzata; Studzian Kazimierz; Szmigiero Leszek; Rybarczyk-Pirek Agnieszka J.; Pfitzner Arno; Cebula-Obrzut Barbara; Smolewski Piotr; Zyner Elzbieta; Ochocki Justyn

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trans-Platinum(II) complex of 3-aminoflavone - synthesis, X-ray crystal structure and biological activities in vitro

机译：3-氨基黄酮的反式铂（II）配合物-体外合成，X射线晶体结构和生物活性

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This paper describes the synthesis of trans-bis-(3-aminoflavone)dichloridoplatinum(II) (trans-Pt(3-af)(2)Cl-2; TCAP) for use as a potential anticancer compound, and the evaluation of its structure by elemental and spectral analyses, and X-ray crystallography. The complex demonstrated a significant cytotoxic effect against human and murine cancer cell lines, as well as weaker toxicity towards healthy cells (human peripheral blood lymphocytes) in comparison with cisplatin. Various biochemical and morphological methods confirm that the proapoptotic activity of trans-Pt(3-af)(2)Cl-2 is markedly higher than the reference cisplatin. Our results suggest that trans-Pt(3-af)(2)Cl-2 may have a different antitumour specificity from that of cisplatin.

机译：本文描述了反式双-（3-氨基黄酮）二氯铂（II）（反式-Pt（3-af）（2）Cl-2; TCAP）的合成及其潜在的抗癌性通过元素和光谱分析以及X射线晶体学分析结构。与顺铂相比，该复合物对人和鼠癌细胞系具有显着的细胞毒性作用，并且对健康细胞（人外周血淋巴细胞）的毒性较弱。各种生化和形态学方法证实，反式Pt（3-af）（2）Cl-2的促凋亡活性明显高于参考顺铂。我们的结果表明，反式Pt（3-af）（2）Cl-2可能具有与顺铂不同的抗肿瘤特异性。

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《Dalton transactions: An international journal of inorganic chemistry》 |2015年第3期|共10页
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Fabijanska Malgorzata; Studzian Kazimierz; Szmigiero Leszek; Rybarczyk-Pirek Agnieszka J.; Pfitzner Arno; Cebula-Obrzut Barbara; Smolewski Piotr; Zyner Elzbieta; Ochocki Justyn;
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1. trans-Platinum(II) complex of 3-aminoflavone - synthesis, X-ray crystal structure and biological activities in vitro [J] . Fabijanska Malgorzata, Studzian Kazimierz, Szmigiero Leszek, Dalton transactions: An international journal of inorganic chemistry . 2015,第3期

机译：3-氨基黄酮的反式铂（II）配合物-体外合成，X射线晶体结构和生物活性
2. Cytotoxic trans-platinum(II) complex with 3-hydroxymethylpyridine: Synthesis, X-ray structure and biological activity evaluation [J] . Grabner Sabina, Modec Barbara, Bukovec Natasa, Journal of Inorganic Biochemistry: An Interdisciplinary Journal . 2016,第Null期

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7. trans-Platinum(II) complex of 3-aminoflavone - synthesis, X-ray crystal structure and biological activities in vitro [O] . Fabijanska, M., Studzian, K., Szmigiero, L., 2015

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trans-Platinum(II) complex of 3-aminoflavone - synthesis, X-ray crystal structure and biological activities in vitro

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