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首页> 外文期刊>Dalton transactions: An international journal of inorganic chemistry >Nickel(II) complexes with a flexible piperazinyl moiety: studies on DNA and protein binding and catecholase like properties
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Nickel(II) complexes with a flexible piperazinyl moiety: studies on DNA and protein binding and catecholase like properties

机译：具有柔性哌嗪基部分的镍（II）配合物：DNA和蛋白质结合以及儿茶酚酶样性质的研究

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摘要

Four new mononuclear Ni(II) complexes [Ni(L-1)]ClO4 (1a), [Ni(L-2)]ClO4(1b), [Ni(SCN)(3)(CH3OH)(aminoethylpiperazineH)] (2a), and [Ni(DMSO)(4)(aminoethylpiperazineH)](ClO4)(3)(2b) have been synthesized from two Schiff base ligands [L-1 = 1-phenyl-3-((2-(piperidin-4-yl)ethyl)imino)but-1-en-1-ol and L-2 = 4-((2-(piperazin-1-yl)ethyl)imino)pent-2-en-2-ol] by exploiting the flexibility of the piperazinyl moiety. Structural analysis reveals that 1a and 1b are square planar complexes with piperazine rings in boat conformations whereas hydrolysis of Schiff bases (L-1 and L-2) occurs during formation of octahedral complexes (2a and 2b) with piperazine rings in chair conformations. Screening tests were conducted to quantify the binding ability of complexes (1a, 1b and 2a) towards DNA, BSA and HSA and it was found that square planar complexes (1a and 1b) showed more effective binding properties over octahedral complex (2a). Furthermore, enzyme kinetic studies reflect that square planar complexes (1a and 1b) are also effective in mimicking catecholase like activities over octahedral complex (2a). Among all the complexes, 1a was found to be the most promising molecule among the series due to its large binding affinity towards different bio-macromolecules and higher T.O.N in the catechol oxidation reaction.
机译：四种新的单核Ni（II）络合物[Ni（L-1）] ClO4（1a），[Ni（L-2）] ClO4（1b），[Ni（SCN）（3）（CH3OH）（氨基乙基哌嗪H）]（ 2a）和[Ni（DMSO）（4）（氨乙基哌嗪H）]（ClO4）（3）（2b）已从两个席夫碱配体[L-1 = 1-苯基-3-（（2-（哌啶-4-基）乙基）亚氨基）but-1-烯-1-醇和L-2 = 4-（（（2-（哌嗪-1-基）乙基）亚氨基）戊-2-烯-2-醇]通过利用哌嗪基部分的柔性。结构分析表明，1a和1b是呈船形的哌嗪环的方形平面络合物，而席夫碱（L-1和L-2）的水解发生在椅子构象中带有哌嗪环的八面体络合物（2a和2b）发生。进行筛选测试以量化复合物（1a，1b和2a）对DNA，BSA和HSA的结合能力，并且发现方形平面复合物（1a和1b）显示出比八面体复合物（2a）更有效的结合特性。此外，酶动力学研究表明，方形平面复合物（1a和1b）在模仿儿茶酚酶样活性方面也比八面体复合物（2a）有效。在所有复合物中，由于1a对不同生物大分子的结合亲和力和邻苯二酚氧化反应中较高的T.O.N，它被认为是该系列中最有希望的分子。

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