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首页> 外文期刊>Dalton transactions: An international journal of inorganic chemistry >Facile preparation and bifunctional imaging of Eu-doped GdPO4 nanorods with MRI and cellular luminescence
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Facile preparation and bifunctional imaging of Eu-doped GdPO4 nanorods with MRI and cellular luminescence

机译：掺and的GdPO4纳米棒的MRI和细胞发光的简便制备和双功能成像

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摘要

The biocompatibility of multifunctional nanomaterials is very important for their clinical applications. Herein, the hexagonal crystal Eu-doped GdPO4 nanorods (NRs) in the template of silk fibroin (SF) peptides are successfully synthesized via a mineralization process. The sizes of the Eu-doped GdPO4 NRs with SF peptides (SF-NRs) are similar to 150 nm in length and similar to 10 nm in diameter. The Eu-doped SF-NRs have strong pink luminescence and a mass magnetic susceptibility value of 1.27 emu g(-1) in 20 000 G of magnetic field due to Eu ion doping. The cell test indicates that the Eu-doped SF-NRs obviously promote the viability of cells at an NR concentration of 25-200 mu g mL(-1). A growth mechanism of Eu-doped GdPO4 SF-NRs is proposed to explain their strong cellular luminescence, magnetic resonance (MR) imaging and good cyto-compatibility. Compared to NRs without SF, the Eu-doped SF-NRs not only exhibit a higher effective positive signal-enhancement ability (the longitudinal relaxivity r(1) value is 1.38 (Gd mM s)(-1)) and in vivo T-1 weighted MR imaging enhancement under a 7.0 T MRI system, but also show the better luminescence imaging of living cells under the fluorescence microscope. This indicates that the Eu-doped SF-NRs have potential as T-1 MRI contrast agents and optical imaging probes.
机译：多功能纳米材料的生物相容性对其临床应用非常重要。在此，通过矿化过程成功地合成了丝素蛋白（SF）肽模板中的六方晶Eu掺杂GdPO4纳米棒（NRs）。带有SF肽（SF-NRs）的Eu掺杂GdPO4 NR的大小大约为150 nm，直径大约为10 nm。 Eu掺杂的SF-NRs具有很强的粉红色发光，并且由于Eu离子掺杂，在20000 G的磁场中的质量磁化率值为1.27 emu g（-1）。细胞测试表明，在25-200μg mL（-1）的NR浓度下，掺Eu的SF-NRs明显促进了细胞的活力。提出了Eu掺杂的GdPO4 SF-NRs的生长机理，以解释其强大的细胞发光，磁共振（MR）成像和良好的细胞相容性。与没有SF的NRs相比，Eu掺杂的SF-NRs不仅具有更高的有效正信号增强能力（纵向弛豫度r（1）值为1.38（Gd mM s）（-1））和体内T- 1在7.0 T MRI系统下的加权MR成像增强，但在荧光显微镜下也显示了活细胞更好的发光成像。这表明Eu掺杂的SF-NR具有作为T-1 MRI造影剂和光学成像探针的潜力。

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