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首页> 外文期刊>Dalton transactions: An international journal of inorganic chemistry >PEGylated FePt-Fe3O4 composite nanoassemblies (CNAs): in vitro hyperthermia, drug delivery and generation of reactive oxygen species (ROS)
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PEGylated FePt-Fe3O4 composite nanoassemblies (CNAs): in vitro hyperthermia, drug delivery and generation of reactive oxygen species (ROS)

机译：聚乙二醇化的FePt-Fe3O4复合纳米组件（CNA）：体外热疗，药物输送和活性氧（ROS）的产生

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摘要

Chemothermal therapy is widely used in clinical applications for the treatment of tumors. However, the major challenge is the use of a multifunctional nano platform for significant regression of the tumor. In this study, a simple synthesis of highly aqueous stable, carboxyl enriched, PEGylated mesoporous iron platinum-iron(II, III) oxide (FePt-Fe3O4) composite nanoassemblies (CNAs) by a simple hydrothermal approach is reported. CNAs exhibit a high loading capacity similar to 90 wt% of the anticancer therapeutic drug, doxorubicin (DOX) because of its porous nature and the availability of abundant negatively charged carboxylic groups on its surface. DOX loaded CNAs (CNAs + DOX) showed a pH responsive drug release in a cell-mimicking environment. Furthermore, the release was enhanced by the application of a alternating current magnetic field. CNAs show no appreciable cytotoxicity in mouse fibroblast (L929) cells but show toxic effects in cervical cancer (HeLa) cells at a concentration of similar to 1 mg mL(-1). A suitable composition of CNAs with a concentration of 2 mg mL(-1) can generate a hyperthermic temperature of similar to 43 degrees C. Also, CNAs, because of their Fe and Pt contents, have an ability to generate reactive oxygen species (ROS) in the presence of hydrogen peroxide inside the cancer cells which helps to enhance its therapeutic effects. The synergistic combination of chemotherapy and ROS is very efficient for killing cancer cells.
机译：化学热疗法在临床应用中广泛用于治疗肿瘤。然而，主要挑战是使用多功能纳米平台显着消退肿瘤。在这项研究中，报告了通过简单的水热方法简单合成高水稳定性，富羧基，聚乙二醇化的中孔铁铂-铁（II，III）氧化物（FePt-Fe3O4）复合纳米组件。由于其多孔性质和在其表面上可获得大量带负电荷的羧基，CNA具有类似于抗癌治疗药物阿霉素（DOX）90 wt％的高负载能力。装有DOX的CNA（CNA + DOX）在模拟细胞的环境中显示出pH响应药物释放。此外，通过施加交流磁场增强了释放。 CNA对小鼠成纤维细胞（L929）没有明显的细胞毒性，但对子宫颈癌细胞（HeLa）的毒性却接近1 mg mL（-1）。浓度为2 mg mL（-1）的CNA的合适组成可以产生接近43摄氏度的高温。此外，由于CNA中的Fe和Pt含量，它们具有产生活性氧的能力（ROS） ）在癌细胞内部存在过氧化氢，这有助于增强其治疗效果。化学疗法和ROS的协同组合对于杀死癌细胞非常有效。

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