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首页> 外文期刊>Dalton transactions: An international journal of inorganic chemistry >Pharmacological activity of metal binding agents that alter copper bioavailability
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Pharmacological activity of metal binding agents that alter copper bioavailability

机译：改变铜生物利用度的金属结合剂的药理活性

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摘要

Iron, copper and zinc are required nutrients for many organisms but also potent toxins if misappropriated. An overload of any of these metals can be cytotoxic and ultimately lead to organ failure, whereas deficiencies can result in anemia, weakened immune system function, and other medical conditions. Cellular metal imbalances have been implicated in neurodegenerative diseases, cancer and infection. It is therefore critical for living organisms to maintain careful control of both the total levels and subcellular distributions of these metals to maintain healthy function. This perspective explores several strategies envisioned to alter the bioavailability of metal ions by using synthetic metal-binding agents targeted for diseases where misappropriated metal ions are suspected of exacerbating cellular damage. Specifically, we discuss chemical properties that influence the pharmacological outcome of a subset of metal-binding agents known as ionophores, and review several examples that have shown multiple pharmacological activities in metal-related diseases, with a specific focus on copper.
机译：铁，铜和锌是许多生物体所需的营养素，但如果滥用，也将产生强毒。这些金属中任何一种的超载都可能具有细胞毒性，并最终导致器官衰竭，而缺乏会导致贫血，免疫系统功能减弱和其他医学状况。细胞金属失衡与神经退行性疾病，癌症和感染有关。因此，对于生命有机体而言，保持对这些金属的总水平和亚细胞分布的仔细控制以维持健康功能至关重要。该观点探讨了预期的几种策略，这些策略可通过使用合成金属结合剂来改变金属离子的生物利用度，所述合成金属结合剂针对怀疑滥用金属离子会加剧细胞损伤的疾病。具体来说，我们讨论了化学性质会影响称为离子载体的金属结合剂的一部分的药理结果，并回顾几个显示出在金属相关疾病中具有多种药理活性的实例，其中重点关注铜。

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