Metallamacrocycle formation through dimerization of metal bioconjugates derived from amino acids and peptides

Alvarez Celedonio M.; Garcia-Rodriguez Raul; Miguel Daniel

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Metallamacrocycle formation through dimerization of metal bioconjugates derived from amino acids and peptides

机译：通过二聚化氨基酸和肽衍生的金属生物缀合物形成金属环

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Metallamacrocycles of 12, 16, and 22 members are obtained by deprotonation of the carboxylic group of the side chain of iminopyridine complexes derived from the amino acid beta-alanine, and the peptides Gly-Gly and Gly-Gly-Gly. Instead of the expected intramolecular attack to give tridentate (N, N, O) ligands, the deprotonated carboxylate attacks in an inter-molecular manner to give dimers in which the ligand acts as a bridge bonded in a kappa(2)(N, N') chelating fashion to one metal and as kappa(O) to the other metal. The formation of the dimers is supported by NMR spectroscopy, mass spectrometry and X-ray crystallography.

机译：通过使衍生自氨基酸β-丙氨酸的亚氨基吡啶络合物的侧链的羧基和肽Gly-Gly和Gly-Gly-Gly脱质子化，获得12、16和22个成员的金属环。去质子化的羧酸盐不是以分子内的方式产生三齿（N，N，O）配体，而是以分子间方式产生二聚体，其中的配体充当在kappa（2）（N，N '）与一种金属螯合时尚，而与另一种金属螯合kappa（O）。二聚体的形成通过NMR光谱，质谱和X射线晶体学来支持。

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《Dalton transactions: An international journal of inorganic chemistry》 |2016年第3期|共10页
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Alvarez Celedonio M.; Garcia-Rodriguez Raul; Miguel Daniel;
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1. Metallamacrocycle formation through dimerization of metal bioconjugates derived from amino acids and peptides [J] . Alvarez Celedonio M., Garcia-Rodriguez Raul, Miguel Daniel Dalton transactions: An international journal of inorganic chemistry . 2016,第3期

机译：通过二聚化氨基酸和肽衍生的金属生物缀合物形成金属环
2. #delta#-Peptide Analogues of Pyranosyl-RNA Nucleo-#delta#-peptides Derived from Conformationally Constrained Nucleo-#delta#-amino Acids:NMR Study of the Duplex Formed by Self-pairing of the (1'S,2'S,4'S)-(phba)-Nucleo-#delta#-peptide(AATAT) [J] . Schwalbe Harald, Wermuth Jochen, Richter Christian, Helvetica chimica acta . 2000,第6期

机译：构型受限的核-δ-氨基酸衍生的吡喃糖基-RNA核-δ-肽的δ-肽类似物：（1'S，2'S，4'S）-的自配对形成双链体的NMR研究（phba）-核-＃δ＃-肽（AATAT）
3. #delta#-Peptide Analogues of Pyranosyl-RNA Nucleo-#delta#-peptides Derived from Conformationally Constrained Nucleo-#delta#-amino Acids:Proparation of Monomers [J] . Karig Gunter, Fuchs Andreas, Busing Arne, Helvetica chimica acta . 2000,第6期

机译：构象受限的核-δ-氨基酸衍生的吡喃糖基-RNA核-δ-肽的δ-肽类似物：单体的制备
4. Tumor-Targeted Bioconjugate Based Delivery of Camptothecin: Programming the Release Rate and Site Using Amino Acid and Peptide Linkers [C] . Controlled Release Society annual meeting . 2004

机译：基于肿瘤的生物缀合物的携带肿瘤蛋白：使用氨基酸和肽接头编程释放速率和网站
5. Observations on the ruminal protein degradation products and the absorption of ruminally derived free and peptide-bound amino acids via ovine forestomach epithelia in vitro. [D] . Jayawardena, Vajira P. 2000

机译：观察绵羊瘤胃上皮细胞中瘤胃蛋白质降解产物以及瘤胃来源的游离氨基酸和与肽结合的氨基酸的吸收。
6. The assimilation of amino-acids by bacteria. 13. The effect of certain amino-acids on the accumulation of free glutamic acid by Staphylococcus aureus: extracellular peptide formation [O] . E. F. Gale, Marguerite B. Van Halteren 1951

机译：细菌对氨基酸的同化作用。 13.某些氨基酸对金黄色葡萄球菌积累游离谷氨酸的影响：细胞外肽的形成
7. Metallamacrocycle formation through dimerization of metal bioconjugates derived from amino acids and peptides [O] . Celedonio M. Álvarez, Raúl García-Rodríguez, Daniel Miguel 2016

机译：通过衍生自氨基酸和肽的金属生物缀合物二聚体的金属茂循环形成
8. Glutamate is the Endogenous Amino Acid Selectively Released by Rat Hippocampal Mossy Fiber Synaptosomes Concomitantly with Prodynorphin-Derived Peptides. [R] . Terrian, D. M., Gannon, R. L., Rea, M. A. 1990

机译：谷氨酸是由大鼠海马苔藓纤维突触体选择性释放的内源性氨基酸，同时与脯氨酸衍生肽一起释放。

Metallamacrocycle formation through dimerization of metal bioconjugates derived from amino acids and peptides

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