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首页> 外文期刊>Dalton transactions: An international journal of inorganic chemistry >A facile ultrasonication assisted method for Fe3O4@SiO2-Ag nanospheres with excellent antibacterial activity
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A facile ultrasonication assisted method for Fe3O4@SiO2-Ag nanospheres with excellent antibacterial activity

机译：Fe3O4 @ SiO2-Ag纳米球的便捷超声辅助方法

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摘要

To increase the monodispersity of magnetic hybrid nanocomposites, a novel ultrasonic method was introduced to synthesize uniform Fe3O4@SiO2-Ag nanospheres. The immobilized Ag nanocrystals were tunable by varying the experimental conditions. An antibacterial assay indicated that the Fe3O4@SiO2-Ag nanospheres exhibited excellent antibacterial activities against Staphylococcus aureus and Escherichia coli, in which the minimum inhibition concentrations (MIC) were 40 mu g mL(-1) and 20 mu g mL(-1), respectively. The live/dead bacterial cell fluorescence stain assay agreed well with the antibacterial assay. The CCK-8 results indicated these nanospheres were bio-compatible for human normal cells and presented relative cytotoxicity against HepG2 tumor cells. These nanospheres could be easily uptaken by the cells and they could affect bacterial cells both inside and outside the cell membrane, which enable them to be promisingly applied in future biomedical areas.
机译：为了提高磁性杂化纳米复合材料的单分散性，引入了一种新颖的超声方法来合成均匀的Fe3O4 @ SiO2-Ag纳米球。通过改变实验条件可以对固定化的Ag纳米晶体进行调谐。抗菌测定表明，Fe3O4 @ SiO2-Ag纳米球对金黄色葡萄球菌和大肠杆菌具有优异的抗菌活性，其最小抑菌浓度（MIC）为40μg mL（-1）和20μgmL（-1） ， 分别。活/死细菌细胞荧光染色测定与抗菌测定非常吻合。 CCK-8结果表明，这些纳米球对人类正常细胞具有生物相容性，并呈现出对HepG2肿瘤细胞的相对细胞毒性。这些纳米球很容易被细胞吸收，并可能影响细胞膜内外的细菌细胞，使其有希望在未来的生物医学领域得到应用。

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