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首页> 外文期刊>Journal of Agricultural and Food Chemistry >Fumonisin B-glucose reaction products are less toxic when fed to swine
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Fumonisin B-glucose reaction products are less toxic when fed to swine

机译:伏马毒素B-葡萄糖反应产物喂猪时毒性较小

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摘要

The effects of fumonisin B-glucose reaction products in swine diets was examined. Pigs were fed diets containing 528 μ mol of total fumonisin B/kg (FB), 528 μ mol of total FB-glucose adducts/kg (FB-G, 122 μ mol of unreacted FB/kg), or Opmol of total FB/kg for 15 days to test the efficacy of the FB-G reaction products in detoxifying FB. Weight gain in FB pigs was lower than in FB-G or controls, which was correlated with feed intake reduction in FB pigs. Serum aspartate aminotransferase, γ-glutamyltransferase, and total bilirubin in FB pigs were higher than in FB-G or control pigs. Serum sphinganine/shingosine ratios in FB pigs were higher than in FB-G or control pigs. Microscopic examination of tissues from FB pigs showed generalized liver necrosis and apoptosis with marked cellular pleomorphism and disorganized hepatic cords. The liver and kidneys in the FB-G group appeared to be normal. Tissues of controls were free of lesions. Results suggest that dietary FB-G products are less toxic to swine and may provide an detoxification approach in instances of widespread FB grain contamination (p < 0.05).
机译:检查了伏马毒素B-葡萄糖反应产物在猪日粮中的作用。猪日粮中的伏马菌素总含量为528μmol / kg(FB),总FB葡萄糖加合物为528μmol / kg(FB-G,未反应的FB / kg 122μmol)或总FB /每公斤体重15天,以测试FB-G反应产物对FB排毒的功效。 FB猪的体重增加低于FB-G或对照组,这与FB猪的采食量减少有关。 FB猪的血清天冬氨酸转氨酶,γ-谷氨酰转移酶和总胆红素均高于FB-G或对照猪。 FB猪的血清鞘氨醇/ shingosine比值高于FB-G或对照猪。 FB猪组织的显微镜检查显示出广泛的肝坏死和凋亡,具有明显的细胞多态性和肝索混乱。 FB-G组的肝肾似乎正常。对照组织无损伤。结果表明,日粮FB-G产品对猪的毒性较小,并且在广泛的FB谷物污染的情况下可以提供一种解毒方法(p&LT; 0.05)。

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