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首页> 外文期刊>Journal of Agricultural and Food Chemistry >Insulin Secretagogue Bioactivity of Finger Citron Fruit (Citrus medica L. var. Sarcodactylis Hort, Rutaceae)
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Insulin Secretagogue Bioactivity of Finger Citron Fruit (Citrus medica L. var. Sarcodactylis Hort, Rutaceae)

机译:手指柚子果实的胰岛素促分泌素生物活性(柑桔,Sartodactylis Hort,芸香科)

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摘要

Finger citron [Citrus medica L. var. Sarcodactylis Hort, Rutaceae] (FC) fruits, widely cultivated in Japan, the southern provinces of China and Taiwan, are commonly used as functional vegetables and preserved as sweetmeats. Previously we identified the major compounds in essential oils (% in EO) of FC fruits to be d-limonene (51.24),γ-terpenene (33.71), α-pinene (3.40), and β-pinene (2.88). Documented evidence on its insulin secretion characteristics is still lacking. In parallel to compositional analysis, we performed in vivo the safety, hypoglycemic, and antidiabetic tests in Sprague-Dawley-SPF rats and Wistar DIO rats respectively. By kinetic analysis on the hypoglycemic patterns of the intraperitoneal glucose tolerance (IPGTT) and the insulin-glucose tolerance tests (IGTT), its insulin secretagogue effect was confirmed. In conclusion, FC fruits that concomitantly possess insulin secretagogue and slimming effects would be very beneficial to type 2 diabetes mellitus patients.
机译:手指香tron [柑桔。在日本,中国的南部省份和台湾广泛种植的果实类水果(Sarcodactylis Hort,Rutaceae)(FC)通常用作功能性蔬菜并保存为甜食。先前,我们确定了FC水果精油中的主要化合物(以EO中的百分比表示)为d-柠檬烯(51.24),γ-萜烯(33.71),α-pine烯(3.40)和β-pine烯(2.88)。仍缺乏有关其胰岛素分泌特性的书面证据。在进行成分分析的同时,我们分别在Sprague-Dawley-SPF大鼠和Wistar DIO大鼠中进行了体内安全性,降糖和抗糖尿病试验。通过腹膜内葡萄糖耐量(IPGTT)的降血糖模式的动力学分析和胰岛素葡萄糖耐量试验(IGTT),证实了其胰岛素促分泌作用。总之,同时具有胰岛素促分泌作用和减肥作用的FC水果对2型糖尿病患者非常有益。

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