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首页> 外文期刊>Journal of Agricultural and Food Chemistry >Antrocamphin A, an Anti-inflammatory Principal from the Fruiting Body of Taiwanofungus camphoratus, and Its Mechanisms
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Antrocamphin A, an Anti-inflammatory Principal from the Fruiting Body of Taiwanofungus camphoratus, and Its Mechanisms

机译：台湾香樟子实体子中的一种抗炎因子——anthocamphin A及其作用机理

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摘要

The fungus Taiwanofungus camphoratus is commonly used for medicinal purposes in Taiwan. It is used as a detoxicant for food poisoning and considered to be a precious folk medicine for hepatoprotection and anti-inflammation. In this study, a lipopolysaccaride (LPS)-challenged ICR mouse acute inflammation model and a LPS-induced macrophage model were used to evaluate the anti-inflammatory activity of T. camphoratus. Ethanol extract of T. camphoratus significantly inhibited expression of iNOS and COX-2 in the liver of LPS-challenged acute inflammatory mice. The ethyl acetate fraction and its isolated compound, antrocamphin A, significantly suppressed nitriteitrate concentration in LPS-challenged RAW 264.7 cells. Antrocamphin A showed potent anti-inflammatory activity by suppressing pro-inflammatory molecule release via the down-regulation of iNOS and COX-2 expression through the NF-κB pathway. This study, therefore, first demonstrates the bioactive compound of T. camphoratus and illustrates the mechanism by which it confers its antiinflammatory activity.
机译：台湾真菌樟脑真菌（Taiwanofungus camphoratus）通常在台湾用于药用。它被用作食物中毒的除毒剂，被认为是保护肝脏和消炎的珍贵民间药。在这项研究中，脂多糖（LPS）挑战的ICR小鼠急性炎症模型和LPS诱导的巨噬细胞模型用于评估樟脑衣原体的抗炎活性。樟脑乙醇提取物可显着抑制LPS攻击的急性炎症小鼠肝脏中iNOS和COX-2的表达。乙酸乙酯级分及其分离的化合物，海马A，显着抑制了LPS挑战的RAW 264.7细胞中的亚硝酸盐/硝酸盐浓度。 Antrocamphin A通过抑制iNOS和NF-κB通路下调COX-2的表达来抑制促炎分子的释放，从而显示出强大的抗炎活性。因此，这项研究首先证明了樟脑衣原体的生物活性化合物，并阐明了其赋予抗炎活性的机制。

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