Design, Multicomponent Synthesis, and Bioactivities of Novel Neonicotinoid Analogues with 1,4-Dihydropyridine Scaffold

Wenwen Zhang; Xiaobao Yang; Weidong Chen

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Design, Multicomponent Synthesis, and Bioactivities of Novel Neonicotinoid Analogues with 1,4-Dihydropyridine Scaffold

机译：1,4-二氢吡啶支架的新型烟碱类似物的设计，多组分合成和生物活性

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Novel neonicotinoid analogues bearing a 1,4-dihydropridine scaffold were designed and synthesized by multicomponent reactions (MCRs) to enhance π-π stacking. The synthesized compounds were identified by ~1H NMR, ~(13)C NMR, high-resolution mass spectroscopy, and elemental analysis. Bioassay tests showed that some of them exhibited high insecticidal activities against pea aphid (Aphis craccivora).

机译：通过多组分反应（MCR）设计和合成了带有1,4-二氢吡啶骨架的新型新烟碱类似物，以增强π-π堆积。通过〜1H NMR，〜（13）C NMR，高分辨率质谱和元素分析鉴定合成的化合物。生物测定测试表明，其中一些对豌豆蚜虫（Aphis craccivora）表现出很高的杀虫活性。

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《Journal of Agricultural and Food Chemistry》 |2010年第5期|共5页
作者
Wenwen Zhang; Xiaobao Yang; Weidong Chen;
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正文语种 eng
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关键词
1; 4-Dihydropridine; MCRs; biological activity;

机译：1;4-二氢吡啶;MCRs;生物学活性;

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1. Design, Multicomponent Synthesis, and Bioactivities of Novel Neonicotinoid Analogues with 1,4-Dihydropyridine Scaffold [J] . Wenwen Zhang, Xiaobao Yang, Weidong Chen Journal of Agricultural and Food Chemistry . 2010,第5期

机译：1,4-二氢吡啶支架的新型烟碱类似物的设计，多组分合成和生物活性
2. Green approach for synthesis of bioactive Hantzsch 1,4-dihydropyridine derivatives based on thiophene moiety via multicomponent reaction [J] . M. G. Sharma, D. P. Rajani, H. M. Patel Royal Society Open Science . 2017,第6期

机译：通过多组分反应合成基于噻吩部分的生物活性Hantzsch 1,4-二氢吡啶衍生物的绿色方法
3. Microwave-assisted combinatorial synthesis of hexa-substituted 1,4-dihydropyridines scaffolds using one-pot two-step multicomponent reaction followed by a S-alkylation [J] . Li M, Zuo ZQ, Wen LR, Journal of combinatorial chemistry . 2008,第3期

机译：微波辅助组合合成一锅两步多组分反应后进行S-烷基化的六取代的1,4-二氢吡啶骨架
4. Microwave-Assisted One-Pot Multicomponent Synthesis of 1,4-Dihydropyridine Derivatives using Nanochitosan [C] . D. Febriantini, A. H. Cahyana, R. T. Yunarti, International Symposium on Current Progress in Mathematics and Sciences . 2019

机译：使用纳米分组的微波辅助1罐多组分合成1,4-二氢吡啶衍生物
5. Enantioselective total synthesis of (-)-kaitocephalin, and, The design and synthesis of a scaffold for kaitocephalin analogues and glutamate receptor ligands using a natural product-based library approach. [D] . Vaswani, Rishi G. 2007

机译：（-）-海头脑素的对映选择性全合成，以及，使用基于天然产物的文库方法设计和合成海头脑类似物和谷氨酸受体配体的支架。
6. Green approach for synthesis of bioactive Hantzsch 14-dihydropyridine derivatives based on thiophene moiety via multicomponent reaction [O] . M. G. Sharma, D. P. Rajani, H. M. Patel 2017

机译：通过多组分反应合成基于噻吩部分的生物活性Hantzsch 14-二氢吡啶衍生物的绿色方法
7. Microwave-assisted one-pot multicomponent synthesis of 1,4-dihydropyridine derivatives using nanochitosan [O] . D. Febriantini, A. H. Cahyana, R. T. Yunarti, 2019

机译：使用纳米分组的微波辅助1罐多组分合成1,4-二氢吡啶衍生物

Design, Multicomponent Synthesis, and Bioactivities of Novel Neonicotinoid Analogues with 1,4-Dihydropyridine Scaffold

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