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首页> 外文期刊>Journal of Agricultural and Food Chemistry >China: Forward to the Green Pesticides via a Basic
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China: Forward to the Green Pesticides via a Basic

机译：中国：通过基本方式向绿色农药转移

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The 973 Program is China's keystone national research program established to support basic research in natural and physical sciences. In addition to promoting the development of core technology and scientific infrastructure needed to enable China to meet the social and economic challenges of the 21st century, the training and mentoring of the new generation of China's young scientists are also important objectives of this national program. The green chemical pesticide research program is a part of the 973 Program. The main objectives of stage 1 of the green chemical pesticide research program (2003-2008) are to establish China's capability to conduct basic research in the discovery of "green" crop protection chemicals that are not only novel in mode of action and highly selective to pest species that are unique to China's agricultural situation but also possess favorable environmental and human hazard and risk potentials. The target-based discovery strategy was selected as the main discovery platform. This strategy not only provided this research program the best chance to discover new products but also provided members of this research team opportunities to establish core technologies in chemoinformatics/computation-aided pesticide design using QSAR, QAAR, sensitive and selective bioassay methodology, combinatorial synthesis, hit to lead optimization, and biological targets that were derived from resistance-AChE, IGR, nAChR, etc. On the basis of the learning from stage 1, stage 2 (2010-2014) of this program will focus on the molecular target-oriented innovation of green chemical pesticides. This commentary presents key learnings and accomplishments from the stage 1 of China's green chemical pesticide research program. It is hoped that this information will stimulate further constructive collaborations between pesticide scientists from China and abroad.
机译：973计划是中国的重点国家研究计划，旨在支持自然科学和物理科学的基础研究。除了促进使中国能够应对21世纪的社会和经济挑战所需的核心技术和科学基础设施的发展外，新一代中国年轻科学家的培训和指导也是该国家计划的重要目标。绿色化学农药研究计划是973计划的一部分。绿色化学农药研究计划（2003-2008年）第一阶段的主要目标是建立中国开展基础研究的能力，以发现“绿色”作物保护化学物质，这些化学物质不仅作用方式新颖，而且对农药的选择性高。中国农业状况特有的害虫种类，但也具有有利的环境和人类危害及潜在风险。选择基于目标的发现策略作为主要发现平台。该策略不仅为该研究计划提供了发现新产品的最佳机会，而且还为该研究小组的成员提供了使用QSAR，QAAR，敏感和选择性生物测定方法，组合合成，化学信息学/计算机辅助农药设计建立核心技术的机会。获得领先的优化，以及从抗性AChE，IGR，nAChR等获得的生物学目标。在从该计划的第1阶段（第2阶段（2010-2014年））学习的基础上，我们将重点关注面向分子目标创新绿色化学农药。该评论介绍了中国绿色化学农药研究计划第一阶段的主要学习成果和取得的成就。希望这些信息将促进中外农药科​​学家之间进一步的建设性合作。

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