...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Agricultural and Food Chemistry >Acetylcholinesterase Inhibitory Activity of Volatile Oil from Peltophorum dasyrachis Kurz ex Bakar (Yellow Batai) and Bisabolane-Type Sesquiterpenoids
【24h】

Acetylcholinesterase Inhibitory Activity of Volatile Oil from Peltophorum dasyrachis Kurz ex Bakar (Yellow Batai) and Bisabolane-Type Sesquiterpenoids

机译：Paktophorum dasyrachis Kurz ex Bakar（黄色Batai）和Bisabolane型倍半萜类化合物的挥发油对乙酰胆碱酯酶的抑制活性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In this study, the chemical compositions and acetylcholinesterase (AChE) inhibitory activitiy of the volatile oil from the bark of Peltophorum dasyrachis Kurz ex Bakar (yellow batai) were evaluated. As a result, 68 compounds, accounting for 88.0% of the total oil, were identified. The main characteristic constituent in P. dasyrachis was isolated by silica gel column chromatography and found to be a sesquiterpenoid, (+)-(S)-ar-turmerone (1). In the AChE inhibitory assay, the volatile oil showed potent inhibitory activity with the IC_(50) value of 83.2 ± 2.8 μg/mL. Among the volatile oil components and characteristic sesquiterpenoids, (+)-(S)-ar-turmerone (1) and (+)-(S)-dihydro-ar-turmerone (2) were potent compounds, inhibiting AChE in a dose-dependent manner, with IC_(50) values of 191.1 ± 0.3 and 81.5 ± 0.2 μM, respectively. (+)-(S)-Dihydro-ar-turmerone (2), in particular, was found to be the most potent AChE inhibitor. Also, bisabolane-type sesquiterpenoid derivatives, (+)-(7S,9S)-ar-turmerol (3), (+)-(7S,9R)-ar-turmerol (4), (+)-(7S,9S)-dihydro-ar-turmerol (5), (+)-(7S,9R)-dihydro-ar-turmerol (6), (+)-(S)-ar-curcumene (7), and (+)-(S)-dihydro-ar-curcumene (8), were synthesized and tested for their AChE inhibitory effect, and their structure-activity relationships were evaluated. All sesquiterpenoids exhibited AChE inhibitory activity. The order of AChE inhibitory potency by bisabolane-type sesquiterpenoids was as follows: ketones > alcohols > hydrocarbons. Furthermore, the inhibition kinetics analyzed by Dixon plots indicated that (+)-(S)-ar-turmerone (1) is a competitive inhibitor, with a K_i value of 882.1 ± 2.1 μM, whereas (+)-(S)-dihydro-ar-turmerone (2) is a noncompetitive inhibitor.
机译：在这项研究中，评估了来自Peltophorum dasyrachis Kurz ex Bakar（黄色batai）皮中的挥发油的化学成分和乙酰胆碱酯酶（AChE）抑制活性。结果，鉴定出68种化合物，占总油量的88.0％。用硅胶柱色谱法分离了假单胞菌的主要特征成分，发现是倍半萜类化合物，（+）-（S）-ar-turmerone（1）。在AChE抑制试验中，挥发油显示出有效的抑制活性，IC_（50）值为83.2±2.8μg/ mL。在挥发油成分和特征性倍半萜中，（+）-（S）-ar-turmerone（1）和（+）-（S）-dihydro-ar-turmerone（2）是有效的化合物，在剂量范围内抑制AChE。依赖方式，IC_（50）值分别为191.1±0.3和81.5±0.2μM。特别地，发现（+）-（S）-二氢-ar- Turmerone（2）是最有效的AChE抑制剂。此外，双七硼烷型倍半萜衍生物，（+）-（7S，9S）-ar-turmerol（3），（+）-（7S，9R）-ar-turmerol（4），（+）-（7S，9S ）-二氢-ar-turmerol（5），（+）-（7S，9R）-二氢-ar-turmerol（6），（+）-（S）-ar-姜黄烯（7）和（+）-合成（S）-二氢芳基姜黄素（8）并测试其对AChE的抑制作用，并评估其构效关系。所有倍半萜均显示出AChE抑制活性。 Bisabolane型倍半萜对AChE抑制能力的顺序如下：酮>醇>烃。此外，通过狄克逊图分析的抑制动力学表明，（+）-（S）-ar-turmerone（1）是竞争性抑制剂，K_i值为882.1±2.1μM，而（+）-（S）-dihydro -ar-turmerone（2）是一种非竞争性抑制剂。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号